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- W4244133098 abstract "Inflammation, allergy and asthma are the manifestation of multitude reactions of biological, cellular and immunological events [[1]Naik S.R. Wala S.M. Inflammation, allergy and asthma, complex immune origin diseases: mechanisms and therapeutic agents.Recent Pat Inflamm Allergy Drug Discov. 2013; 7: 62-95Crossref PubMed Scopus (41) Google Scholar]. Furthermore, a study confirmed that asthma is a chronic disease of the innate and adaptive immune systems responding to viruses and allergens [[2]Holtzman M.J. Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens.J Clin Invest. 2012; 122: 2741-2748Crossref PubMed Scopus (117) Google Scholar]. Increased arterial stiffness is associated with some autoimmune-inflammatory diseases such as systemic lupus erythematosus and rheumatoid arthritis [3Yildiz M. Soy M. Kurum T. Ozbay G. Increased pulse wave velocity and shortened pulse wave propagation time in young patients with rheumatoid arthritis.Can J Cardiol. 2004; 20: 1097-1100PubMed Google Scholar, 4Selzer F. Sutton-Tyrrell K. Fitzgerald S. Tracy R. Kuller L. Manzi S. Vascular stiffness in women with systemic lupus erythematosus.Hypertension. 2001; 37: 1075-1082Crossref PubMed Scopus (249) Google Scholar, 5Soltesz P. Kerekes G. Der H. et al.Comparative assessment of vascular function in autoimmune rheumatic diseases: considerations of prevention and treatment.Autoimmun Rev. 2011; 10: 416-425Crossref PubMed Scopus (93) Google Scholar]. Recent genetic studies have revealed specific genes that may contribute to arterial stiffening. The genes may be involved in transcriptional pathways controlling gene expression, differentiation of vascular smooth muscle cells, apoptosis of endothelial cells, or the immune response within the vascular wall [[6]Lacolley P. Challande P. Osborne-Pellegrin M. Regnault V. Genetics and pathophysiology of arterial stiffness.Cardiovasc Res. 2009; 81: 637-648Crossref PubMed Scopus (128) Google Scholar]. Immune dysfunction are involved in asthma, Behçet's disease and psoriasis. Further studies are warranted to determine the association between arterial stiffen and immunological parameters. We agreed that arterial stiffness combined with other biological markers may supply more information to clinicians. Our results showed that high sensitivity C-reactive protein was positively correlated with brachial-ankle pulse wave velocity in patients with severe asthma. However, it is a long journey from bench to bedside. It needs the cooperation from multiple disciplines and confirmation from different research groups in clinical practice." @default.
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- W4244133098 date "2014-06-01" @default.
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- W4244133098 title "Response to Letter to the Editor" @default.
- W4244133098 doi "https://doi.org/10.1016/j.rmed.2014.03.007" @default.
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