Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244157658> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4244157658 endingPage "195" @default.
- W4244157658 startingPage "189" @default.
- W4244157658 abstract "The cholecystokinin (CCK-B) agonist pentagastrin stimulates dose-dependent release of adrenocorticotropin (ACTH) and cortisol in humans, likely via direct pharmacological action at pituitary CCK-B receptors. Pentagastrin also produces side effects, however, which may be experienced as novel or anxiety arousing and could contribute to ACTH release. Available data suggest that pentagastrin's activation of the hypothalamic-pituitary-adrenal (HPA) axis is unrelated to anxiety symptoms themselves, but novelty effects have not been examined in this model and do strongly activate this system in animals. To further explore the impact of novelty and anxiety symptoms on HPA responses, pentagastrin was administered twice to 12 subjects (six male, six female) under single-blind conditions. Repeat pentagastrin injection was associated with a slight habituation in the magnitude of symptom and HPA axis responses, but robust HPA and symptom responses were seen following both injections. No relationships were found between anxiety symptoms and HPA activity and the modest symptomatic and neuroendocrine habituation appeared to occur independently. Pentagastrin may release ACTH and cortisol through direct pharmacological action, perhaps enhanced on first exposure by psychologically mediated novelty effects. Novelty, per se, is not likely the primary mediator of the HPA response. This model may be useful for further study of cognitive-emotional modulators of HPA axis activity." @default.
- W4244157658 created "2022-05-12" @default.
- W4244157658 creator A5049791651 @default.
- W4244157658 date "2004-05-01" @default.
- W4244157658 modified "2023-10-17" @default.
- W4244157658 title "Effect of repeat exposure on neuroendocrine and symptom responses to pentagastrin" @default.
- W4244157658 doi "https://doi.org/10.1016/s0165-1781(04)00064-2" @default.
- W4244157658 hasPublicationYear "2004" @default.
- W4244157658 type Work @default.
- W4244157658 citedByCount "0" @default.
- W4244157658 crossrefType "journal-article" @default.
- W4244157658 hasAuthorship W4244157658A5049791651 @default.
- W4244157658 hasConcept C104745856 @default.
- W4244157658 hasConcept C118552586 @default.
- W4244157658 hasConcept C126322002 @default.
- W4244157658 hasConcept C134018914 @default.
- W4244157658 hasConcept C15744967 @default.
- W4244157658 hasConcept C169760540 @default.
- W4244157658 hasConcept C170493617 @default.
- W4244157658 hasConcept C2777504413 @default.
- W4244157658 hasConcept C2778738651 @default.
- W4244157658 hasConcept C2778938600 @default.
- W4244157658 hasConcept C2779377912 @default.
- W4244157658 hasConcept C2779422922 @default.
- W4244157658 hasConcept C50610925 @default.
- W4244157658 hasConcept C558461103 @default.
- W4244157658 hasConcept C71315377 @default.
- W4244157658 hasConcept C71924100 @default.
- W4244157658 hasConcept C77805123 @default.
- W4244157658 hasConceptScore W4244157658C104745856 @default.
- W4244157658 hasConceptScore W4244157658C118552586 @default.
- W4244157658 hasConceptScore W4244157658C126322002 @default.
- W4244157658 hasConceptScore W4244157658C134018914 @default.
- W4244157658 hasConceptScore W4244157658C15744967 @default.
- W4244157658 hasConceptScore W4244157658C169760540 @default.
- W4244157658 hasConceptScore W4244157658C170493617 @default.
- W4244157658 hasConceptScore W4244157658C2777504413 @default.
- W4244157658 hasConceptScore W4244157658C2778738651 @default.
- W4244157658 hasConceptScore W4244157658C2778938600 @default.
- W4244157658 hasConceptScore W4244157658C2779377912 @default.
- W4244157658 hasConceptScore W4244157658C2779422922 @default.
- W4244157658 hasConceptScore W4244157658C50610925 @default.
- W4244157658 hasConceptScore W4244157658C558461103 @default.
- W4244157658 hasConceptScore W4244157658C71315377 @default.
- W4244157658 hasConceptScore W4244157658C71924100 @default.
- W4244157658 hasConceptScore W4244157658C77805123 @default.
- W4244157658 hasIssue "3" @default.
- W4244157658 hasLocation W42441576581 @default.
- W4244157658 hasOpenAccess W4244157658 @default.
- W4244157658 hasPrimaryLocation W42441576581 @default.
- W4244157658 hasRelatedWork W1973606441 @default.
- W4244157658 hasRelatedWork W2014661051 @default.
- W4244157658 hasRelatedWork W2027913950 @default.
- W4244157658 hasRelatedWork W2050423574 @default.
- W4244157658 hasRelatedWork W2056454041 @default.
- W4244157658 hasRelatedWork W2077993809 @default.
- W4244157658 hasRelatedWork W2101411396 @default.
- W4244157658 hasRelatedWork W2401702418 @default.
- W4244157658 hasRelatedWork W2748952813 @default.
- W4244157658 hasRelatedWork W3200229029 @default.
- W4244157658 hasVolume "126" @default.
- W4244157658 isParatext "false" @default.
- W4244157658 isRetracted "false" @default.
- W4244157658 workType "article" @default.