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- W4244203439 abstract "The expression of neural cell adhesion molecules and myelin-specific molecules is precisely regulated according to cell type and developmental age. We investigated whether different isoforms of these molecules change during development of oligodendrocytes. Immature oligodendrocytes cultured from embryonic day 18 rat cerebrum were distinguished into early stage and late stage by morphological and immunocytochemical criteria. mRNA levels of the neural cell adhesion molecule L1 in late-stage immature oligodendrocytes were approximately fivefold higher than in early-stage cells, but early-stage immature oligodendrocytes predominantly expressed an L1 spliced isoform lacking two region (exon 2 and 27). Late-stage cells expressed full-length L1 identical to the neuronal form. mRNA for the neural cell adhesion molecules NCAM and MAG did not show any difference in expression pattern. These results suggest that alternatively spliced isoforms of L1 might be regulated by temporal and spatial factors during oligodendrocyte development." @default.
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- W4244203439 date "2000-06-01" @default.
- W4244203439 modified "2023-09-30" @default.
- W4244203439 title "Differential expression of alternatively spliced neural cell adhesion molecule l1 isoforms during oligodendrocyte maturation" @default.
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- W4244203439 doi "https://doi.org/10.1002/(sici)1097-4547(20000601)60:5<579::aid-jnr2>3.0.co;2-" @default.
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