Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244254341> ?p ?o ?g. }
- W4244254341 endingPage "4" @default.
- W4244254341 startingPage "4" @default.
- W4244254341 abstract "Age-related macular degeneration (AMD) is the leading cause of legal blindness in older people in the developed world. The disease involves damage to the part of the retina responsible for central vision. Degeneration of retinal pigment epithelial (RPE) cells, photoreceptors, and choriocapillaris may contribute to visual loss. Over the past decades, scientists and clinicians have tried to replace lost RPE cells in patients with AMD using cells from different sources. In recent years, advances in generating RPE cells from stem cells have been made and clinical trials are currently evaluating the safety and efficiency of replacing the degenerated RPE cell layer with stem cell–derived RPE cells. However, the therapeutic success of transplantation of stem cell–derived RPE cells may be limited unless the transplanted cells can adhere and survive in the long term in the diseased eye. One hallmark of AMD is the altered extracellular environment of Bruch's membrane to which the grafted cells have to adhere. Here, we discuss recent approaches to overcome the inhibitory environment of the diseased eye and to enhance the survival rate of transplanted RPE cells. Our aim is to highlight novel approaches that may have the potential to improve the efficacy of RPE transplantation for AMD in the future." @default.
- W4244254341 created "2022-05-12" @default.
- W4244254341 creator A5007382759 @default.
- W4244254341 creator A5024444613 @default.
- W4244254341 date "2014-07-01" @default.
- W4244254341 modified "2023-09-23" @default.
- W4244254341 title "Enhancing RPE Cell-Based Therapy Outcomes for AMD: The Role of Bruch's Membrane" @default.
- W4244254341 cites W115097612 @default.
- W4244254341 cites W1258969883 @default.
- W4244254341 cites W1480779622 @default.
- W4244254341 cites W1485340008 @default.
- W4244254341 cites W1491905380 @default.
- W4244254341 cites W1507327514 @default.
- W4244254341 cites W1599485077 @default.
- W4244254341 cites W1604526865 @default.
- W4244254341 cites W1898328784 @default.
- W4244254341 cites W1964681839 @default.
- W4244254341 cites W1964936056 @default.
- W4244254341 cites W1966300591 @default.
- W4244254341 cites W1969263624 @default.
- W4244254341 cites W1970528463 @default.
- W4244254341 cites W1974378004 @default.
- W4244254341 cites W1975161314 @default.
- W4244254341 cites W1977014939 @default.
- W4244254341 cites W1977694732 @default.
- W4244254341 cites W1979182288 @default.
- W4244254341 cites W1982040962 @default.
- W4244254341 cites W1988201752 @default.
- W4244254341 cites W1988410112 @default.
- W4244254341 cites W1989369048 @default.
- W4244254341 cites W1991037959 @default.
- W4244254341 cites W1992425768 @default.
- W4244254341 cites W1992915966 @default.
- W4244254341 cites W1993096645 @default.
- W4244254341 cites W1993616615 @default.
- W4244254341 cites W1993638375 @default.
- W4244254341 cites W1994009311 @default.
- W4244254341 cites W1994813393 @default.
- W4244254341 cites W1994984356 @default.
- W4244254341 cites W1997049126 @default.
- W4244254341 cites W1997480136 @default.
- W4244254341 cites W1997830580 @default.
- W4244254341 cites W2001248401 @default.
- W4244254341 cites W2002340857 @default.
- W4244254341 cites W2002429523 @default.
- W4244254341 cites W2004117352 @default.
- W4244254341 cites W2006988527 @default.
- W4244254341 cites W2007952958 @default.
- W4244254341 cites W2008289317 @default.
- W4244254341 cites W2009004700 @default.
- W4244254341 cites W2009661588 @default.
- W4244254341 cites W2011752292 @default.
- W4244254341 cites W2013712854 @default.
- W4244254341 cites W2013744830 @default.
- W4244254341 cites W2016411285 @default.
- W4244254341 cites W2017136158 @default.
- W4244254341 cites W2017530678 @default.
- W4244254341 cites W2021124272 @default.
- W4244254341 cites W2023642934 @default.
- W4244254341 cites W2024688714 @default.
- W4244254341 cites W2024786266 @default.
- W4244254341 cites W2025126013 @default.
- W4244254341 cites W2028270615 @default.
- W4244254341 cites W2029119558 @default.
- W4244254341 cites W2029936186 @default.
- W4244254341 cites W2030550749 @default.
- W4244254341 cites W2032888143 @default.
- W4244254341 cites W2033673310 @default.
- W4244254341 cites W2034018544 @default.
- W4244254341 cites W2035318710 @default.
- W4244254341 cites W2037272767 @default.
- W4244254341 cites W2037531698 @default.
- W4244254341 cites W2038106981 @default.
- W4244254341 cites W2040434386 @default.
- W4244254341 cites W2045048112 @default.
- W4244254341 cites W2047393488 @default.
- W4244254341 cites W2047814322 @default.
- W4244254341 cites W2048107972 @default.
- W4244254341 cites W2048140742 @default.
- W4244254341 cites W2048560811 @default.
- W4244254341 cites W2049342495 @default.
- W4244254341 cites W2049531589 @default.
- W4244254341 cites W2052504496 @default.
- W4244254341 cites W2055311311 @default.
- W4244254341 cites W2055489304 @default.
- W4244254341 cites W2058607314 @default.
- W4244254341 cites W2058624823 @default.
- W4244254341 cites W2062112670 @default.
- W4244254341 cites W2062460463 @default.
- W4244254341 cites W2063200478 @default.
- W4244254341 cites W2064963302 @default.
- W4244254341 cites W2067072602 @default.
- W4244254341 cites W2068014194 @default.
- W4244254341 cites W2068815747 @default.
- W4244254341 cites W2068844645 @default.
- W4244254341 cites W2070209352 @default.
- W4244254341 cites W2070628315 @default.
- W4244254341 cites W2072015641 @default.