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- W4244262965 abstract "The effect of organic acids on the production of macrolide antibiotics by a strain of S. venezuelae MCRL–0376 was studied. Organic acids such as, citric, succinic, acetic, malic, malonic and fumaric acid etc. stimulated antibiotic production, while propionic acid which is reported to be incorporated into an aglycone of macrolide antibiotics showed inhibitory effects on the growth and antibiotic production. However, in the presence of lipoic acid, propionic acid acted as other organic acids. Addition of organic acids in the medium caused the accumulation of narbonolide, an aglycone of narbomycin, by S. venezuelae MCRL–0376, though this compound was not produced in the absence of organic acids. Narbonolide did not inhibit the growth of Bacillus subtilis, but by incubation with washed cell of S. venezuelae MCRL–0376, yielded an antibiotic substance (mainly picromycin) active against this organism. Further, addition of narbonolide in the culture of strain MCRL–0376 enhanced the antibiotic production." @default.
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- W4244262965 date "1974-01-01" @default.
- W4244262965 modified "2023-10-14" @default.
- W4244262965 title "Accumulation of Narbonolide Caused by the Addition of Organic Acids" @default.
- W4244262965 cites W2159403248 @default.
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- W4244262965 doi "https://doi.org/10.1080/00021369.1974.10861126" @default.
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