Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244311005> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4244311005 endingPage "292" @default.
- W4244311005 startingPage "285" @default.
- W4244311005 abstract "Phospholipase A2 (PLA2 catalyzes the hydrolysis of the sn-2 position of membrans glyerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins (PGs) and leukotrienes (LTs). The same reaction also produces lysophosholipids, which represent another class of lipid mediators. So far, at least 19 enzymes that posses PLA2 activity have been identified in mammals. The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of low-molecular-weight, Ca2+-requring, secretory enzymes that have been implicated in a number of biological processes, such as modification of cicosanoid generation, inflammation, host defense, and atheroselecrosis. The cytosolic PLA2 (cPLA2) family consists of 3 enzymes, among which cPLA2α plays an essential role in the initiation of AA metabolism. Intracellular activation of cPLA2α is tightly regulated by Ca2+ and phosphorylation. The Ca2+, independent PLA2 (iPLA2) family contains 2 enzymes and may play a major role in membrane phospholipid remodeling. The platelet-activating factor (PAF) acetylhydrolase (PAF-AH) family represents a unique group of PLA2 that contains 4 enzymes exhibiting unusual substrate specificity toward PAF and/or oxidized phospholipids. In this review, we will overview current understanding of the properties and functions of each enzyme belonging to the sPLA2, cPLA2, and iPLA2, families, which have been implicated in signal transduction." @default.
- W4244311005 created "2022-05-12" @default.
- W4244311005 creator A5030120964 @default.
- W4244311005 creator A5075092495 @default.
- W4244311005 date "2002-03-01" @default.
- W4244311005 modified "2023-10-18" @default.
- W4244311005 title "Phospholipase A2" @default.
- W4244311005 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a003101" @default.
- W4244311005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11872155" @default.
- W4244311005 hasPublicationYear "2002" @default.
- W4244311005 type Work @default.
- W4244311005 citedByCount "413" @default.
- W4244311005 countsByYear W42443110052012 @default.
- W4244311005 countsByYear W42443110052013 @default.
- W4244311005 countsByYear W42443110052014 @default.
- W4244311005 countsByYear W42443110052015 @default.
- W4244311005 countsByYear W42443110052016 @default.
- W4244311005 countsByYear W42443110052017 @default.
- W4244311005 countsByYear W42443110052018 @default.
- W4244311005 countsByYear W42443110052019 @default.
- W4244311005 countsByYear W42443110052020 @default.
- W4244311005 countsByYear W42443110052021 @default.
- W4244311005 countsByYear W42443110052022 @default.
- W4244311005 countsByYear W42443110052023 @default.
- W4244311005 crossrefType "journal-article" @default.
- W4244311005 hasAuthorship W4244311005A5030120964 @default.
- W4244311005 hasAuthorship W4244311005A5075092495 @default.
- W4244311005 hasConcept C11960822 @default.
- W4244311005 hasConcept C119795356 @default.
- W4244311005 hasConcept C12927208 @default.
- W4244311005 hasConcept C134018914 @default.
- W4244311005 hasConcept C180899940 @default.
- W4244311005 hasConcept C181199279 @default.
- W4244311005 hasConcept C185592680 @default.
- W4244311005 hasConcept C2776551241 @default.
- W4244311005 hasConcept C2776888444 @default.
- W4244311005 hasConcept C2778078955 @default.
- W4244311005 hasConcept C2778918659 @default.
- W4244311005 hasConcept C2779020240 @default.
- W4244311005 hasConcept C41625074 @default.
- W4244311005 hasConcept C55493867 @default.
- W4244311005 hasConcept C62478195 @default.
- W4244311005 hasConcept C79879829 @default.
- W4244311005 hasConcept C86803240 @default.
- W4244311005 hasConcept C95444343 @default.
- W4244311005 hasConcept C98539663 @default.
- W4244311005 hasConceptScore W4244311005C11960822 @default.
- W4244311005 hasConceptScore W4244311005C119795356 @default.
- W4244311005 hasConceptScore W4244311005C12927208 @default.
- W4244311005 hasConceptScore W4244311005C134018914 @default.
- W4244311005 hasConceptScore W4244311005C180899940 @default.
- W4244311005 hasConceptScore W4244311005C181199279 @default.
- W4244311005 hasConceptScore W4244311005C185592680 @default.
- W4244311005 hasConceptScore W4244311005C2776551241 @default.
- W4244311005 hasConceptScore W4244311005C2776888444 @default.
- W4244311005 hasConceptScore W4244311005C2778078955 @default.
- W4244311005 hasConceptScore W4244311005C2778918659 @default.
- W4244311005 hasConceptScore W4244311005C2779020240 @default.
- W4244311005 hasConceptScore W4244311005C41625074 @default.
- W4244311005 hasConceptScore W4244311005C55493867 @default.
- W4244311005 hasConceptScore W4244311005C62478195 @default.
- W4244311005 hasConceptScore W4244311005C79879829 @default.
- W4244311005 hasConceptScore W4244311005C86803240 @default.
- W4244311005 hasConceptScore W4244311005C95444343 @default.
- W4244311005 hasConceptScore W4244311005C98539663 @default.
- W4244311005 hasIssue "3" @default.
- W4244311005 hasLocation W42443110051 @default.
- W4244311005 hasLocation W42443110052 @default.
- W4244311005 hasOpenAccess W4244311005 @default.
- W4244311005 hasPrimaryLocation W42443110051 @default.
- W4244311005 hasRelatedWork W131513067 @default.
- W4244311005 hasRelatedWork W1545247531 @default.
- W4244311005 hasRelatedWork W1990842621 @default.
- W4244311005 hasRelatedWork W1994531902 @default.
- W4244311005 hasRelatedWork W2073079404 @default.
- W4244311005 hasRelatedWork W2124374021 @default.
- W4244311005 hasRelatedWork W2197416409 @default.
- W4244311005 hasRelatedWork W2418737946 @default.
- W4244311005 hasRelatedWork W4244311005 @default.
- W4244311005 hasRelatedWork W936412733 @default.
- W4244311005 hasVolume "131" @default.
- W4244311005 isParatext "false" @default.
- W4244311005 isRetracted "false" @default.
- W4244311005 workType "article" @default.