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- W4244316449 abstract "If bone marrow transplantation is to become widely applicable in the treatment of patients with leukemia and aplastic anemia, the necessity to have a perfectly histocompatible donor must be overcome. In an effort to define the roles of HL-A type and mixed lymphocyte culture (MLC) reactivity in the determination of successful engraftment and the occurrence of graftversus-host disease (GVHD), we have attempted transplantation of a child with acute myeloblastic leukemia (AML) using an HL-A identical, MLC-reactive sibling donor. Successful engraftment has been accomplished, as documented by the appearance of multiple donor genetic markers in the recipient. There is no evidence of severe GVHD. The recipient is alive, without evidence of leukemia, and has returned to full activities 9 mo after transplantation. The recipient now produces lymphocytes, which have the MLC reactivity that characterize the donor's lymphocytes, rather than that of her own pretransplant lymphocytes. This experience demonstrates that successful bone marrow transplantation in patients with leukemia can be accomplished in the face of MLC reactivity." @default.
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- W4244316449 date "1976-09-01" @default.
- W4244316449 modified "2023-10-01" @default.
- W4244316449 title "Successful bone marrow transplantation against mixed lymphocyte culture barrier" @default.
- W4244316449 doi "https://doi.org/10.1182/blood.v48.3.385.bloodjournal483385" @default.
- W4244316449 hasPublicationYear "1976" @default.
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