FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244354016> ?p ?o ?g. }

• W4244354016 endingPage "855" @default.
• W4244354016 startingPage "855" @default.
• W4244354016 abstract "This 30-year retrospective analysis by Hoohenkerk and colleagues [1Hoohenkerk G.J.F. Bruggemans E.F. Koolbergen D.R. Rijlaarsdam M.E.B. Hazekamp M.G. Long-term results of reoperation for left atrioventricular valve regurgitation after correction of atrioventricular septal defects.Ann Thorac Surg. 2012; 93: 848-855Abstract Full Text Full Text PDF Scopus (31) Google Scholar] of patients undergoing reoperation for left atrioventricular valve regurgitation (LAVVR) after correction of all types of atrioventricular septal defect (AVSD) is notable for its size and for the fact that it spans nearly the entire era of AVSD repair. The series reinforces already established paradigms of AVSD morphologic findings and repair: first, that failure to close the zone of apposition (“cleft”), incomplete closure, or dehiscence is a significant contributor to residual disease that eventuates in reoperation; second, that AV valve dysplasia, despite being a poorly defined and subjective parameter in most retrospective studies, is nonetheless a significant risk factor for reoperation; and third, that long-term survival is superior in those patients who successfully undergo repair when compared with those who require valve replacement.In the authors' experience, roughly 1 in 7 patients undergoing repair of AVSD underwent reoperation for LAVVR. At first reoperation, 1 in 3 patients required valve replacement. Nearly 30% of patients undergoing an initially successful repair required a second reoperation. Of those patients undergoing a second reoperation, more than half underwent valve replacement. The overall survival among patients who underwent reoperation was roughly 90% at 1 year. Importantly, the analysis does not include any echocardiographic data, so the amount of valve regurgitation present in the patients who did not undergo reoperation is unknown.Late-term results necessarily reflect an earlier era (two thirds of the cohort underwent operation between 1975 and 1985), and one is tempted to suppose that such results will be better for patients who undergo operation today. Indeed, the mean age at primary repair in this series was 3.5 years and 50% of the patients had severe LAVVR preoperatively. It is reasonable to argue that earlier age at repair and a lower tolerance for preoperative valvar dysfunction will translate into higher rates of valve preservation and its attendant benefits for patients who undergo operation in the current era.That said, this important work highlights the fact that despite our best collective efforts, a significant portion of patients undergoing repair of AVSD will carry forward a burden of disease that will necessitate reintervention and impact late survival. This fact underscores the importance of clinical and laboratory investigations focused on establishing better solutions to the problems posed by suboptimal valve anatomy. Alternative anticoagulation strategies may mitigate a portion of valve prostheses' morbidities. However optimal outcomes depend on finding better tissue substitutes to facilitate complex repairs and, ultimately, tissue engineering techniques that are applicable in the clinical arena of valve repair. This 30-year retrospective analysis by Hoohenkerk and colleagues [1Hoohenkerk G.J.F. Bruggemans E.F. Koolbergen D.R. Rijlaarsdam M.E.B. Hazekamp M.G. Long-term results of reoperation for left atrioventricular valve regurgitation after correction of atrioventricular septal defects.Ann Thorac Surg. 2012; 93: 848-855Abstract Full Text Full Text PDF Scopus (31) Google Scholar] of patients undergoing reoperation for left atrioventricular valve regurgitation (LAVVR) after correction of all types of atrioventricular septal defect (AVSD) is notable for its size and for the fact that it spans nearly the entire era of AVSD repair. The series reinforces already established paradigms of AVSD morphologic findings and repair: first, that failure to close the zone of apposition (“cleft”), incomplete closure, or dehiscence is a significant contributor to residual disease that eventuates in reoperation; second, that AV valve dysplasia, despite being a poorly defined and subjective parameter in most retrospective studies, is nonetheless a significant risk factor for reoperation; and third, that long-term survival is superior in those patients who successfully undergo repair when compared with those who require valve replacement. In the authors' experience, roughly 1 in 7 patients undergoing repair of AVSD underwent reoperation for LAVVR. At first reoperation, 1 in 3 patients required valve replacement. Nearly 30% of patients undergoing an initially successful repair required a second reoperation. Of those patients undergoing a second reoperation, more than half underwent valve replacement. The overall survival among patients who underwent reoperation was roughly 90% at 1 year. Importantly, the analysis does not include any echocardiographic data, so the amount of valve regurgitation present in the patients who did not undergo reoperation is unknown. Late-term results necessarily reflect an earlier era (two thirds of the cohort underwent operation between 1975 and 1985), and one is tempted to suppose that such results will be better for patients who undergo operation today. Indeed, the mean age at primary repair in this series was 3.5 years and 50% of the patients had severe LAVVR preoperatively. It is reasonable to argue that earlier age at repair and a lower tolerance for preoperative valvar dysfunction will translate into higher rates of valve preservation and its attendant benefits for patients who undergo operation in the current era. That said, this important work highlights the fact that despite our best collective efforts, a significant portion of patients undergoing repair of AVSD will carry forward a burden of disease that will necessitate reintervention and impact late survival. This fact underscores the importance of clinical and laboratory investigations focused on establishing better solutions to the problems posed by suboptimal valve anatomy. Alternative anticoagulation strategies may mitigate a portion of valve prostheses' morbidities. However optimal outcomes depend on finding better tissue substitutes to facilitate complex repairs and, ultimately, tissue engineering techniques that are applicable in the clinical arena of valve repair. Long-Term Results of Reoperation for Left Atrioventricular Valve Regurgitation After Correction of Atrioventricular Septal DefectsThe Annals of Thoracic SurgeryVol. 93Issue 3PreviewLong-term results of reoperation for left atrioventricular valve regurgitation (LAVVR) after previous correction of atrioventricular septal defect (AVSD) are scarce. We evaluated long-term outcome of reoperation for LAVVR and identified risk factors for reoperation. Full-Text PDF" @default.
• W4244354016 created "2022-05-12" @default.
• W4244354016 creator A5049827639 @default.
• W4244354016 date "2012-03-01" @default.
• W4244354016 modified "2023-10-14" @default.
• W4244354016 title "Invited Commentary" @default.
• W4244354016 doi "https://doi.org/10.1016/j.athoracsur.2011.10.034" @default.
• W4244354016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22364978" @default.
• W4244354016 hasPublicationYear "2012" @default.
• W4244354016 type Work @default.
• W4244354016 citedByCount "0" @default.
• W4244354016 crossrefType "journal-article" @default.
• W4244354016 hasAuthorship W4244354016A5049827639 @default.
• W4244354016 hasConcept C139812875 @default.
• W4244354016 hasConcept C141071460 @default.
• W4244354016 hasConcept C164705383 @default.
• W4244354016 hasConcept C167135981 @default.
• W4244354016 hasConcept C2778921608 @default.
• W4244354016 hasConcept C2780007028 @default.
• W4244354016 hasConcept C2780026749 @default.
• W4244354016 hasConcept C2780074459 @default.
• W4244354016 hasConcept C2780168065 @default.
• W4244354016 hasConcept C2780714102 @default.
• W4244354016 hasConcept C2781301203 @default.
• W4244354016 hasConcept C2910018961 @default.
• W4244354016 hasConcept C2993958809 @default.
• W4244354016 hasConcept C71924100 @default.
• W4244354016 hasConceptScore W4244354016C139812875 @default.
• W4244354016 hasConceptScore W4244354016C141071460 @default.
• W4244354016 hasConceptScore W4244354016C164705383 @default.
• W4244354016 hasConceptScore W4244354016C167135981 @default.
• W4244354016 hasConceptScore W4244354016C2778921608 @default.
• W4244354016 hasConceptScore W4244354016C2780007028 @default.
• W4244354016 hasConceptScore W4244354016C2780026749 @default.
• W4244354016 hasConceptScore W4244354016C2780074459 @default.
• W4244354016 hasConceptScore W4244354016C2780168065 @default.
• W4244354016 hasConceptScore W4244354016C2780714102 @default.
• W4244354016 hasConceptScore W4244354016C2781301203 @default.
• W4244354016 hasConceptScore W4244354016C2910018961 @default.
• W4244354016 hasConceptScore W4244354016C2993958809 @default.
• W4244354016 hasConceptScore W4244354016C71924100 @default.
• W4244354016 hasIssue "3" @default.
• W4244354016 hasLocation W42443540161 @default.
• W4244354016 hasLocation W42443540162 @default.
• W4244354016 hasOpenAccess W4244354016 @default.
• W4244354016 hasPrimaryLocation W42443540161 @default.
• W4244354016 hasRelatedWork W2021995517 @default.
• W4244354016 hasRelatedWork W2056365001 @default.
• W4244354016 hasRelatedWork W2060448482 @default.
• W4244354016 hasRelatedWork W2085446021 @default.
• W4244354016 hasRelatedWork W2097156851 @default.
• W4244354016 hasRelatedWork W2154042480 @default.
• W4244354016 hasRelatedWork W2398416718 @default.
• W4244354016 hasRelatedWork W2468179475 @default.
• W4244354016 hasRelatedWork W3047093066 @default.
• W4244354016 hasRelatedWork W3196245838 @default.
• W4244354016 hasVolume "93" @default.
• W4244354016 isParatext "false" @default.
• W4244354016 isRetracted "false" @default.
• W4244354016 workType "article" @default.