Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244401097> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4244401097 abstract "Abstract Background This study was designed to examine whether severe aortic regurgitation will affect the pharmacodynamics (PD) and pharmacokinetics (PK) of cisatracurium during anesthetic induction. Methods A total of 32 patients were divided into two groups: the AR group (n=16) and the control group (n=16). Arterial blood samples were drawn before and at 1, 2, 4, 6, 8, 10, 16 and 20 minutes after intravenous injection of 0.15mg/kg cisatracurium. TOF tests were applied to determine the onset time of maximal muscle relaxation. The concentration of cisatracurium in plasma was determined by high-performance liquid chromatography. Results The onset time to maximal neuromuscular block was prolonged from 2.07(0.08) minutes to 4.03±0.14 minutes, which indicated that the PD responses to cisatracurium were significantly delayed in the AR group (P<0.05) compared to the control group. A conventional two-compartment PK model showed a higher plasma concentration of cisatracurium among the AR group with markedly reduced intercompartment transfer rate (K12= 0.19±0.02 and K21= 0.11±0.01 in the AR group vs. K12=0.26±0.01 and K21= 0.19±0.01 in the control group, P<0.01) compared to the control group. Conclusion Backward blood flow during diastole in severe AR impaired distribution of cisatracurium from the central compartment to the peripheral compartment, which accounted for the lagged PD responses.Findings in this study underlie the importance of muscular blockade monitoring among patients with severe aortic regurgitation during anesthetic induction." @default.
- W4244401097 created "2022-05-12" @default.
- W4244401097 creator A5004918104 @default.
- W4244401097 creator A5010738468 @default.
- W4244401097 creator A5022727373 @default.
- W4244401097 creator A5033171578 @default.
- W4244401097 creator A5040157342 @default.
- W4244401097 creator A5066366668 @default.
- W4244401097 creator A5079447550 @default.
- W4244401097 creator A5089647276 @default.
- W4244401097 date "2020-01-08" @default.
- W4244401097 modified "2023-10-18" @default.
- W4244401097 title "Abnormal Cisatracurium Pharmacodynamics and Pharmacokinetics among Patients with Severe Aortic Regurgitation during Anesthetic Induction" @default.
- W4244401097 cites W1554071332 @default.
- W4244401097 cites W1963820442 @default.
- W4244401097 cites W2001422027 @default.
- W4244401097 cites W2013577561 @default.
- W4244401097 cites W2016752982 @default.
- W4244401097 cites W2045797470 @default.
- W4244401097 cites W2068535819 @default.
- W4244401097 cites W2091835993 @default.
- W4244401097 cites W2172924801 @default.
- W4244401097 cites W2525203365 @default.
- W4244401097 cites W2551805780 @default.
- W4244401097 cites W2626272824 @default.
- W4244401097 doi "https://doi.org/10.21203/rs.2.16816/v3" @default.
- W4244401097 hasPublicationYear "2020" @default.
- W4244401097 type Work @default.
- W4244401097 citedByCount "0" @default.
- W4244401097 crossrefType "posted-content" @default.
- W4244401097 hasAuthorship W4244401097A5004918104 @default.
- W4244401097 hasAuthorship W4244401097A5010738468 @default.
- W4244401097 hasAuthorship W4244401097A5022727373 @default.
- W4244401097 hasAuthorship W4244401097A5033171578 @default.
- W4244401097 hasAuthorship W4244401097A5040157342 @default.
- W4244401097 hasAuthorship W4244401097A5066366668 @default.
- W4244401097 hasAuthorship W4244401097A5079447550 @default.
- W4244401097 hasAuthorship W4244401097A5089647276 @default.
- W4244401097 hasBestOaLocation W42444010971 @default.
- W4244401097 hasConcept C111113717 @default.
- W4244401097 hasConcept C112705442 @default.
- W4244401097 hasConcept C126322002 @default.
- W4244401097 hasConcept C2776277131 @default.
- W4244401097 hasConcept C2778162923 @default.
- W4244401097 hasConcept C2779676917 @default.
- W4244401097 hasConcept C2780168065 @default.
- W4244401097 hasConcept C42219234 @default.
- W4244401097 hasConcept C71924100 @default.
- W4244401097 hasConceptScore W4244401097C111113717 @default.
- W4244401097 hasConceptScore W4244401097C112705442 @default.
- W4244401097 hasConceptScore W4244401097C126322002 @default.
- W4244401097 hasConceptScore W4244401097C2776277131 @default.
- W4244401097 hasConceptScore W4244401097C2778162923 @default.
- W4244401097 hasConceptScore W4244401097C2779676917 @default.
- W4244401097 hasConceptScore W4244401097C2780168065 @default.
- W4244401097 hasConceptScore W4244401097C42219234 @default.
- W4244401097 hasConceptScore W4244401097C71924100 @default.
- W4244401097 hasLocation W42444010971 @default.
- W4244401097 hasLocation W42444010972 @default.
- W4244401097 hasLocation W42444010973 @default.
- W4244401097 hasOpenAccess W4244401097 @default.
- W4244401097 hasPrimaryLocation W42444010971 @default.
- W4244401097 hasRelatedWork W2067499636 @default.
- W4244401097 hasRelatedWork W2109527111 @default.
- W4244401097 hasRelatedWork W2118332650 @default.
- W4244401097 hasRelatedWork W2136730981 @default.
- W4244401097 hasRelatedWork W2288413177 @default.
- W4244401097 hasRelatedWork W2464527790 @default.
- W4244401097 hasRelatedWork W2562334457 @default.
- W4244401097 hasRelatedWork W2912123072 @default.
- W4244401097 hasRelatedWork W3124874101 @default.
- W4244401097 hasRelatedWork W4244401097 @default.
- W4244401097 isParatext "false" @default.
- W4244401097 isRetracted "false" @default.
- W4244401097 workType "article" @default.