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- W4244405770 abstract "A 45-year-old male patient with Ph-negative chronic myeloid leukemia (CML) had rearranged bcr-3′ and bcr-5#x2032; gene regions in Southern blot studies when leukemia was diagnosed. During development of terminal blast crisis, successive blood samples showed a progressive decrease in the amount of germline bcr DNA and its complete loss by full blast crisis. There were also increased amounts of rearranged bcr DNA consistent with acquired homozygosity. A similar result was obtained with an IgV lambda probe and indicated homozygosity of a significant part of chromosome 22. The bcr-abl gene complex behaves as a somatic dominant in CML, and we suggest that its acquired homozygosity is a mechanism of bcr-abl amplification similar to duplication of the Ph chromosome commonly found in the blast crisis of CML." @default.
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- W4244405770 date "1988-07-01" @default.
- W4244405770 modified "2023-09-29" @default.
- W4244405770 title "Acquired homozygosity of the rearranged bcr allele during the acute leukemic phase of a patient with Ph-negative chronic myeloid leukemia" @default.
- W4244405770 doi "https://doi.org/10.1182/blood.v72.1.24.bloodjournal72124" @default.
- W4244405770 hasPublicationYear "1988" @default.
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