FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244421137> ?p ?o ?g. }

• W4244421137 endingPage "3978" @default.
• W4244421137 startingPage "3965" @default.
• W4244421137 abstract "Expression of the rat alpha 1-acid glycoprotein gene is stimulated by interleukin-1 (IL-1) and interleukin-6 (IL-6) and is synergistically enhanced by the combination of the two. The distal regulatory element (DRE), a 142-base-pair (bp) sequence located 5 kilobase pairs upstream of the transcriptional start site, appears to be crucial for this cytokine response. The cytokine-specific regulatory sequences within the DRE have been identified by inserting individual DRE subregions, selected combinations of these, or a few linker mutated fragments into a plasmid containing an enhancerless simian virus 40 promoter linked to the chloramphenicol acetyltransferase gene. The regulatory activity was determined in transiently transfected human and rat hepatoma cells. The IL-1 response region was confined to the 5'-most 62 bp of the DRE, and its function seemed to depend on at least two separate components. The same region was also responsive to phorbol ester treatment. The IL-6 regulatory function was dependent on a 54-bp sequence located within the 3' half of the DRE. When the IL-1 response region was recombined with the IL-6 regulatory region of the DRE or with IL-6 response elements of other plasma protein genes, a strong cooperative action by IL-1 and IL-6 was achieved. The functional DRE sequences were recognized by nuclear proteins extracted from rat liver and hepatoma cells. However, no cytokine-inducible binding activity was detectable, which suggests that transcriptional regulation through the DRE might be controlled by posttranslational modification of constitutively bound trans-acting factors." @default.
• W4244421137 created "2022-05-12" @default.
• W4244421137 creator A5026258553 @default.
• W4244421137 creator A5033429257 @default.
• W4244421137 date "1990-08-01" @default.
• W4244421137 modified "2023-10-16" @default.
• W4244421137 title "The cytokine response element of the rat alpha 1-acid glycoprotein gene is a complex of several interacting regulatory sequences" @default.
• W4244421137 cites W126863029 @default.
• W4244421137 cites W1486833195 @default.
• W4244421137 cites W1496710035 @default.
• W4244421137 cites W1528354595 @default.
• W4244421137 cites W1537924198 @default.
• W4244421137 cites W1541596961 @default.
• W4244421137 cites W1556565864 @default.
• W4244421137 cites W1558516755 @default.
• W4244421137 cites W1599779948 @default.
• W4244421137 cites W1605415092 @default.
• W4244421137 cites W1636165650 @default.
• W4244421137 cites W1829456503 @default.
• W4244421137 cites W1921007038 @default.
• W4244421137 cites W1931481640 @default.
• W4244421137 cites W1965258786 @default.
• W4244421137 cites W1965372133 @default.
• W4244421137 cites W1968213454 @default.
• W4244421137 cites W1970197409 @default.
• W4244421137 cites W1972310182 @default.
• W4244421137 cites W1973135307 @default.
• W4244421137 cites W1974217676 @default.
• W4244421137 cites W1981071038 @default.
• W4244421137 cites W1983920076 @default.
• W4244421137 cites W1994484797 @default.
• W4244421137 cites W1998108444 @default.
• W4244421137 cites W2004907641 @default.
• W4244421137 cites W2005131012 @default.
• W4244421137 cites W2005484362 @default.
• W4244421137 cites W2031635601 @default.
• W4244421137 cites W2033697361 @default.
• W4244421137 cites W2036903205 @default.
• W4244421137 cites W2037463093 @default.
• W4244421137 cites W2037540469 @default.
• W4244421137 cites W2045135216 @default.
• W4244421137 cites W2045457726 @default.
• W4244421137 cites W2047232671 @default.
• W4244421137 cites W2051139385 @default.
• W4244421137 cites W2060333964 @default.
• W4244421137 cites W2060903877 @default.
• W4244421137 cites W2072585523 @default.
• W4244421137 cites W2075840772 @default.
• W4244421137 cites W2083490046 @default.
• W4244421137 cites W2095184753 @default.
• W4244421137 cites W2099600512 @default.
• W4244421137 cites W2102154746 @default.
• W4244421137 cites W2129787999 @default.
• W4244421137 cites W2144206181 @default.
• W4244421137 cites W2149563853 @default.
• W4244421137 cites W2171336713 @default.
• W4244421137 cites W219183814 @default.
• W4244421137 cites W2340683598 @default.
• W4244421137 cites W2343104470 @default.
• W4244421137 cites W311570066 @default.
• W4244421137 cites W408517226 @default.
• W4244421137 cites W4230001666 @default.
• W4244421137 cites W4231386602 @default.
• W4244421137 cites W4236535537 @default.
• W4244421137 cites W4253923417 @default.
• W4244421137 cites W958315937 @default.
• W4244421137 doi "https://doi.org/10.1128/mcb.10.8.3965-3978.1990" @default.
• W4244421137 hasPublicationYear "1990" @default.
• W4244421137 type Work @default.
• W4244421137 citedByCount "3" @default.
• W4244421137 crossrefType "journal-article" @default.
• W4244421137 hasAuthorship W4244421137A5026258553 @default.
• W4244421137 hasAuthorship W4244421137A5033429257 @default.
• W4244421137 hasConcept C101762097 @default.
• W4244421137 hasConcept C104317684 @default.
• W4244421137 hasConcept C150194340 @default.
• W4244421137 hasConcept C153911025 @default.
• W4244421137 hasConcept C165864922 @default.
• W4244421137 hasConcept C167625842 @default.
• W4244421137 hasConcept C21592294 @default.
• W4244421137 hasConcept C2778690821 @default.
• W4244421137 hasConcept C2780730277 @default.
• W4244421137 hasConcept C54009773 @default.
• W4244421137 hasConcept C54355233 @default.
• W4244421137 hasConcept C55493867 @default.
• W4244421137 hasConcept C86803240 @default.
• W4244421137 hasConcept C95444343 @default.
• W4244421137 hasConceptScore W4244421137C101762097 @default.
• W4244421137 hasConceptScore W4244421137C104317684 @default.
• W4244421137 hasConceptScore W4244421137C150194340 @default.
• W4244421137 hasConceptScore W4244421137C153911025 @default.
• W4244421137 hasConceptScore W4244421137C165864922 @default.
• W4244421137 hasConceptScore W4244421137C167625842 @default.
• W4244421137 hasConceptScore W4244421137C21592294 @default.
• W4244421137 hasConceptScore W4244421137C2778690821 @default.
• W4244421137 hasConceptScore W4244421137C2780730277 @default.
• W4244421137 hasConceptScore W4244421137C54009773 @default.
• W4244421137 hasConceptScore W4244421137C54355233 @default.

• next