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- W4244429595 abstract "We sell hope.... Only a few years ago, this much-quoted self-assessment of the cosmetic industry accurately portrayed the state of the art. No sophisticated consumer, let alone scientist, had any expectation that the unattractive concomitants of skin aging could truly be reversed. The article by Weiss and coworkers<sup>1</sup>in this issue ofThe Journalsuggests that a new age has dawned. See also p 527. The University of Michigan investigators<sup>1</sup>present strong evidence that the wrinkling, sallowness, roughness, and mottled pigmentation characteristic of habitually exposed skin of middle-aged and elderly Caucasions can be improved within a four-month period by daily topical application of all<i>trans</i>-retinoic acid (tretinoin). In each subject, the left forearm and face were randomly treated with either 0.1% tretinoin cream or vehicle cream control, while the right forearm received the other preparation. Comparisons with the pretreatment state were made on five occasions during the" @default.
- W4244429595 created "2022-05-12" @default.
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- W4244429595 date "1988-01-22" @default.
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- W4244429595 title "At last! A medical treatment for skin aging" @default.
- W4244429595 doi "https://doi.org/10.1001/jama.259.4.569" @default.
- W4244429595 hasPublicationYear "1988" @default.
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