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• W4244440162 abstract "Abstract Background Whether TILs plays different roles in different molecular subtypes breast cancer remains unknown. The prognostic and predictive value of TILs in different molecular subtypes breast cancer is still controversy. The aim of our meta-analysis is to assess the prognostic and predictive value of TILs in different molecular subtypes breast cancer by summarizing all relevant studies including multivariate analysis. Methods PubMed, Embase, EBSCO, ScienceDirect, Cochrane Database and the Web of Science were comprehensively retrieved (until March 2020). Hazard ratio (HR), odds ratio (OR) and their 95% confidence intervals (CI) were used as effect measures to perform our meta-analysis. Random effect model was used. Stata software, version 15 (2017) (Stata Corp, College Station, TX, USA) was used to carried out statistical analysis. Results Thirty-three studies including 18170 eligible breast cancer patients were analyzed. The meta-analysis showed that patients with high TILs expression were significantly correlated with increased pCR after neoadjuvant chemotherapy in HER2 enriched molecular subtype (OR = 1.137, 95% CI [1.061~1.218], p <0.001) and TNBC molecular subtype breast cancer (OR = 1.120, 95% CI [1.061~1.182], p <0.001). But, patients with high TILs expression were not significantly related to high pCR in luminal molecular subtype breast cancer after neoadjuvant chemotherapy (OR =1.154, 95% CI [0.789~1.690], p = 0.460). We carried out this meta-analysis on HR for OS and DFS to assess the prognostic value of TILs in breast cancer with different molecular subtypes more deeply. Our meta-analysis confirmed that high TILs had relationship with a significantly improved DFS in HER2 enriched molecular subtype [HR=0.940, 95%CI (0.903~0.979), p =0.003] and TNBC molecular subtype breast cancer patients [HR=0.907, 95%CI (0.862~0.954), p <0.001]. However, high TILs was not correlated with a significantly better DFS in luminal molecular subtype breast cancer patients [HR=0.998, 95%CI (0.977~1.019), p =0.840]. Furthermore, the results confirmed that high TILs had significant relationship with a better OS in HER2 enriched molecular subtype [HR=0.910, 95%CI (0.866~0.957), p <0.001] and TNBC molecular subtype breast cancer patients [HR=0.869, 95%CI (0.836~0.904), p <0.001]. Conversely, the summarized results indicated that high TILs was significantly correlated with a poor OS in luminal molecular subtype breast cancer patients [HR=1.077, 95%CI (1.016~1.141), p =0.012]. Conclusions Our meta-analysis confirms that high TILs is correlated with favourable survival and predicts pathological complete response in breast cancer patients with TNBC molecular subtypes and HER2-enriched molecular subtypes." @default.
• W4244440162 created "2022-05-12" @default.
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• W4244440162 date "2020-07-17" @default.
• W4244440162 modified "2023-09-26" @default.
• W4244440162 title "Predictive and Prognostic Role of Tumor Infiltrating Lymphocytes in Breast Cancer Patients With Different Molecular Subtypes: a Meta-Analysis" @default.
• W4244440162 doi "https://doi.org/10.21203/rs.3.rs-42520/v1" @default.
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