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- W4244489461 abstract "Anaemia and iron deficiency are important co-morbidities and both may lead to reduced exercise capacity. The impact of new onset anaemia in the progression of heart failure needs to be defined. A total of 280 patients with stable chronic HF (mean age: 67±11 y, 21% female, left ventricular ejection fraction [LVEF] 39±13%, body mass index [BMI] 29.3±5.5 kg/m2, New York Heart Association [NYHA] class 2.3±0.6, diabetes mellitus 30%, glomerular filtration rate 53.1±15.6 mL/min) were enrolled from 2010 and followed until April 2014 or until they reached a combined endpoint of death, incident anaemia, or a haemoglobin (Hb) drop >1 g/dL. Anaemia was defined according to World Health Organization criteria [Hb <13 g/dL in men, <12 g/dL in women], microcytic anaemia as mean corpuscular volume (MCV) ≤80fl, macrocytic anaemia as MCV≥96fl. Iron deficiency (ID) was defined as serum ferritin <100 μg/L or ferritin <300 μg/L with transferrin saturation (TSAT) <20%. Exercise capacity was assessed by spiroergometry (peakVO2) and 6-minute walk test (6MWT). A total of 37 (13.2%) Patients died from any cause during a mean follow-up of 26±14 months. At baseline, 88 (31%) patients presented with anaemia, 140 (50%) with ID. Of the anaemic patients 62 were found to have normocytic, 12 macrocytic and 14 microcytic anaemia. Hb levels correlated with peakVO2 (r=0.299, p<0.001). In patients with both ID and anaemia (n=60, 21%) exercise capacity was significantly lower than in patients with ID or anaemia alone. At the first follow-up visit after 8±4 months, 25 patients presented with incident anaemia. A total of 76 patients reached the combined endpoint within 26±14 month. Cox regression analysis showed higher risk with higher NYHA class (hazard ratio [HR]: 1.484, 95% CI:1.03-2.13, p=0.03) and lower risk in patients without artrial fibrillation (HR:0.62, 95%CI:0.39-0.98, p=0.04), without pacemaker devices (HR: 0.59, 95%CI:0.37-0.93, p=0.02), with higher LVEF (HR:0.973, 95%CI: 0.89-1.11, p=0.005). A trend was observed for peak VO2 (HR:0.94, 95%CI:0.889-1.002, p=0.059). Exercise capacity is correlated with haemoglobin values. The impact of anaemia on reduced exercise capacity is stronger than that of ID." @default.
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- W4244489461 date "2014-08-01" @default.
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- W4244489461 title "Risk Factors of Anaemia-Development in Patients with Chronic Heart Failure: Results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)" @default.
- W4244489461 doi "https://doi.org/10.1016/j.cardfail.2014.06.111" @default.
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