FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244544834> ?p ?o ?g. }

• W4244544834 endingPage "660" @default.
• W4244544834 startingPage "652" @default.
• W4244544834 abstract "Fabry disease may be treated by enzyme replacement therapy (ERT), but the impact of chronic kidney disease (CKD) on the response to therapy remains unclear. The aim of the present study was to analyse the incidence and predictors of clinical events in patients on ERT.Multicentre retrospective observational analysis of patients diagnosed and treated with ERT for Fabry disease. The primary outcome was the first renal, neurological or cardiological events or death during a follow-up of 60 months (24-120).In 69 patients (42 males, 27 females, mean age 44.6±13.7 years), at the end of follow-up, eGFR and the left ventricular septum thickness remained stable and the urinary albumin: creatinine ratio tended to decrease, but this decrease only approached significance in patients on agalsidase-beta (242-128mg/g (p=0.05). At the end of follow-up, 21 (30%) patients had suffered an incident clinical event: 6 renal, 2 neurological and 13 cardiological (including 3 deaths). Events were more frequent in patients with baseline eGFR≤60ml/min/1.73m2 (log Rank 12.423, p=0.001), and this remained significant even after excluding incident renal events (log Rank 4.086, p=0.043) and in males and in females. Lower baseline eGFR was associated with a 3- to 7-fold increase the risk of clinical events in different Cox models.GFR at the initiation of ERT is the main predictor of clinical events, both in males and in females, suggesting that start of ERT prior to the development of CKD is associated with better outcomes." @default.
• W4244544834 created "2022-05-12" @default.
• W4244544834 creator A5001999066 @default.
• W4244544834 creator A5002307334 @default.
• W4244544834 creator A5006165967 @default.
• W4244544834 creator A5023390869 @default.
• W4244544834 creator A5024303362 @default.
• W4244544834 creator A5027821329 @default.
• W4244544834 creator A5028122653 @default.
• W4244544834 creator A5029611097 @default.
• W4244544834 creator A5042622500 @default.
• W4244544834 creator A5045903783 @default.
• W4244544834 creator A5047800254 @default.
• W4244544834 creator A5055840067 @default.
• W4244544834 creator A5058542854 @default.
• W4244544834 creator A5060498655 @default.
• W4244544834 creator A5063245254 @default.
• W4244544834 creator A5064467700 @default.
• W4244544834 creator A5065173777 @default.
• W4244544834 creator A5076952603 @default.
• W4244544834 creator A5078883177 @default.
• W4244544834 creator A5080719934 @default.
• W4244544834 creator A5080910351 @default.
• W4244544834 creator A5088765975 @default.
• W4244544834 date "2021-11-01" @default.
• W4244544834 modified "2023-10-17" @default.
• W4244544834 title "Predictors of outcome in a Spanish cohort of patients with Fabry disease on enzyme replacement therapy" @default.
• W4244544834 cites W1997129653 @default.
• W4244544834 cites W2015981234 @default.
• W4244544834 cites W2044012755 @default.
• W4244544834 cites W2074616175 @default.
• W4244544834 cites W2079324568 @default.
• W4244544834 cites W2094976188 @default.
• W4244544834 cites W2107743168 @default.
• W4244544834 cites W2117239948 @default.
• W4244544834 cites W2128635057 @default.
• W4244544834 cites W2138239752 @default.
• W4244544834 cites W2138506456 @default.
• W4244544834 cites W2141145283 @default.
• W4244544834 cites W2155965977 @default.
• W4244544834 cites W2167600303 @default.
• W4244544834 cites W2259834771 @default.
• W4244544834 cites W2302389118 @default.
• W4244544834 cites W2420386625 @default.
• W4244544834 cites W2562426643 @default.
• W4244544834 cites W2611485951 @default.
• W4244544834 cites W2701712891 @default.
• W4244544834 cites W2739876826 @default.
• W4244544834 cites W2779212318 @default.
• W4244544834 cites W2789753965 @default.
• W4244544834 cites W2800511996 @default.
• W4244544834 cites W2802547448 @default.
• W4244544834 cites W2893439500 @default.
• W4244544834 cites W4235568098 @default.
• W4244544834 doi "https://doi.org/10.1016/j.nefroe.2022.01.003" @default.
• W4244544834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36165155" @default.
• W4244544834 hasPublicationYear "2021" @default.
• W4244544834 type Work @default.
• W4244544834 citedByCount "2" @default.
• W4244544834 countsByYear W42445448342022 @default.
• W4244544834 countsByYear W42445448342023 @default.
• W4244544834 crossrefType "journal-article" @default.
• W4244544834 hasAuthorship W4244544834A5001999066 @default.
• W4244544834 hasAuthorship W4244544834A5002307334 @default.
• W4244544834 hasAuthorship W4244544834A5006165967 @default.
• W4244544834 hasAuthorship W4244544834A5023390869 @default.
• W4244544834 hasAuthorship W4244544834A5024303362 @default.
• W4244544834 hasAuthorship W4244544834A5027821329 @default.
• W4244544834 hasAuthorship W4244544834A5028122653 @default.
• W4244544834 hasAuthorship W4244544834A5029611097 @default.
• W4244544834 hasAuthorship W4244544834A5042622500 @default.
• W4244544834 hasAuthorship W4244544834A5045903783 @default.
• W4244544834 hasAuthorship W4244544834A5047800254 @default.
• W4244544834 hasAuthorship W4244544834A5055840067 @default.
• W4244544834 hasAuthorship W4244544834A5058542854 @default.
• W4244544834 hasAuthorship W4244544834A5060498655 @default.
• W4244544834 hasAuthorship W4244544834A5063245254 @default.
• W4244544834 hasAuthorship W4244544834A5064467700 @default.
• W4244544834 hasAuthorship W4244544834A5065173777 @default.
• W4244544834 hasAuthorship W4244544834A5076952603 @default.
• W4244544834 hasAuthorship W4244544834A5078883177 @default.
• W4244544834 hasAuthorship W4244544834A5080719934 @default.
• W4244544834 hasAuthorship W4244544834A5080910351 @default.
• W4244544834 hasAuthorship W4244544834A5088765975 @default.
• W4244544834 hasBestOaLocation W42445448341 @default.
• W4244544834 hasConcept C120665830 @default.
• W4244544834 hasConcept C121332964 @default.
• W4244544834 hasConcept C126322002 @default.
• W4244544834 hasConcept C141071460 @default.
• W4244544834 hasConcept C159641895 @default.
• W4244544834 hasConcept C167135981 @default.
• W4244544834 hasConcept C201903717 @default.
• W4244544834 hasConcept C2777404818 @default.
• W4244544834 hasConcept C2778653478 @default.
• W4244544834 hasConcept C2779134260 @default.
• W4244544834 hasConcept C2779541074 @default.
• W4244544834 hasConcept C2779969927 @default.
• W4244544834 hasConcept C2780306776 @default.

• next