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• W4244608556 abstract "Previously our group showed the potential use of a score (IPS) based on MGMT, NDRG-1 and PHLDA-3 immunohistochemistry (IHC) expression as strong prognosis factor in operated PanNET (Viúdez et al. Oncotarget 2016). The present retrospective multicenter project analyzes the predictive/prognosis role of MGMT, NDRG-1 and PHLDA-3 IHCs in patients with advanced PanNET treated CAPTEM or everolimus. IHC nuclear staining for MGMT and PHLDA-3 is being scored as 0, 1-5%, 6-50% and ≥ 51%. For NDRG-1, we are using a cytoplasmic score from 0 to 2 based on distribution pattern (null, patched or diffuse). mIPS was calculated based on those IHC expressions 0% IHC expression for MGMT: 0 pt; < 5% PHLDA3: 0 pt; null or weak intensity NDRG1 expression: 0 point (min: 0 pt, max: 4 pts). 78 of 105 pts have been fully analyzed, 39 of them women (50%) and median age of 61 (27-81). 35 pts were treated with CAPTEM and 43 pts with everolimus. Median previous lines were 2 (20.5% received chemotherapy previously), and 90.5% pts had ki67 < 20%. 63%, 12% and 26.8% were null for MGMT, NDRG-1 and PHLDA-3 IHC analysis. In the entire cohort K-M analysis showed significant differences for PFS or OS based on best response and mIPS, p=0.0001 and p=0.002, respectively. Significant differenced were also observed for OS based on number previous lines received (p=0.011) or mIPS (p=0.016). In pts treated with everolimus, log rank analysis showed significant differences for PFS (p=0.007 HR: 0.136 CI95%: 0.032-0.575) based on our mSPI. Similar results were observed in CAPTEM cohort for PFS (p=0.033 HR: 3.56 CI95%: 1.11-11.45) according to original IPS. From our knowledge it is the first time that a simple IHC score could be useful to predict outcome in PanNET pts treated with everolimus or CAPTEM. More mature results and analyses of our project are needed and will be presented during 2020 ESMO World Congress on GI Cancer." @default.
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• W4244608556 date "2020-07-01" @default.
• W4244608556 modified "2023-10-16" @default.
• W4244608556 title "P-245 GETNET-SILVELUL study: An original or modified immunohistochemical score (IPS or mIPS) in patients (pts) with pancreatic neuroendocrine tumors (PanNET) treated with everolimus or CAPTEM" @default.
• W4244608556 doi "https://doi.org/10.1016/j.annonc.2020.04.327" @default.
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