Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244611088> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W4244611088 endingPage "616" @default.
- W4244611088 startingPage "610" @default.
- W4244611088 abstract "Patients with noninsulin-dependent diabetes mellitus exhibit increased proportions of plasma proinsulin and proinsulin conversion intermediates. We used hyperinsulinemic diabetic and nondiabetic Psammomys obesus to study the possible relationship between steady state pancreatic insulin stores and the proportion of proinsulin-related peptides in the plasma and pancreas. Insulin-like peptides were separated by reverse phase HPLC and identified by pulse-chase experiments. A marked increase in the proportions of proinsulin and proinsulin conversion intermediates in the plasma and pancreas of diabetic nonfasted Psammomys was associated with 90% reduction in insulin stores of the pancreas. After a 16- to 20-h fast, the depletion of pancreatic insulin in the diabetic animals was partially corrected, and the proinsulin/insulin ratio was normalized. In contrast, nondiabetic Psammomys showed only 50% reduction in pancreatic insulin stores under nonfasting conditions, with no change in the proinsulin/insulin ratio. These findings suggest that in the diabetic Psammomys obesus, the pancreatic capacity for storage of insulin may be limited; the metabolic consequences of this limitation are amplified by increased secretory demand secondary to insulin resistance, thus facilitating the establishment of hyperglycemia, which may in itself further exacerbate pancreatic dysfunction." @default.
- W4244611088 created "2022-05-12" @default.
- W4244611088 creator A5052372079 @default.
- W4244611088 date "1994-08-01" @default.
- W4244611088 modified "2023-09-26" @default.
- W4244611088 title "Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus" @default.
- W4244611088 doi "https://doi.org/10.1210/en.135.2.610" @default.
- W4244611088 hasPublicationYear "1994" @default.
- W4244611088 type Work @default.
- W4244611088 citedByCount "12" @default.
- W4244611088 countsByYear W42446110882012 @default.
- W4244611088 crossrefType "journal-article" @default.
- W4244611088 hasAuthorship W4244611088A5052372079 @default.
- W4244611088 hasConcept C126322002 @default.
- W4244611088 hasConcept C134018914 @default.
- W4244611088 hasConcept C2778764654 @default.
- W4244611088 hasConcept C2779306644 @default.
- W4244611088 hasConcept C555293320 @default.
- W4244611088 hasConcept C71924100 @default.
- W4244611088 hasConcept C86803240 @default.
- W4244611088 hasConcept C90061646 @default.
- W4244611088 hasConceptScore W4244611088C126322002 @default.
- W4244611088 hasConceptScore W4244611088C134018914 @default.
- W4244611088 hasConceptScore W4244611088C2778764654 @default.
- W4244611088 hasConceptScore W4244611088C2779306644 @default.
- W4244611088 hasConceptScore W4244611088C555293320 @default.
- W4244611088 hasConceptScore W4244611088C71924100 @default.
- W4244611088 hasConceptScore W4244611088C86803240 @default.
- W4244611088 hasConceptScore W4244611088C90061646 @default.
- W4244611088 hasIssue "2" @default.
- W4244611088 hasLocation W42446110881 @default.
- W4244611088 hasOpenAccess W4244611088 @default.
- W4244611088 hasPrimaryLocation W42446110881 @default.
- W4244611088 hasRelatedWork W1987930707 @default.
- W4244611088 hasRelatedWork W2029605369 @default.
- W4244611088 hasRelatedWork W2038508340 @default.
- W4244611088 hasRelatedWork W2040934062 @default.
- W4244611088 hasRelatedWork W2064751303 @default.
- W4244611088 hasRelatedWork W2068300193 @default.
- W4244611088 hasRelatedWork W2079112323 @default.
- W4244611088 hasRelatedWork W2094895170 @default.
- W4244611088 hasRelatedWork W2169847732 @default.
- W4244611088 hasRelatedWork W302189978 @default.
- W4244611088 hasVolume "135" @default.
- W4244611088 isParatext "false" @default.
- W4244611088 isRetracted "false" @default.
- W4244611088 workType "article" @default.