Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244611479> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4244611479 abstract "Abstract Background: A considerable number of muscle development-related genes were differentially expressed in the early stage of avian adipocyte differentiation. However, the functions of them in adipocyte differentiation remain largely known. In this study, the myoblast determination protein 1 (MYOD1) was selected as a representative of muscle development and we investigated its expression, function and regulation in avian adipocyte differentiation. Results: The expression of MYOD1 decreased significantly in the early stage of avian adipocyte differentiation. CRISPR/CAS9-mediated deletion of MYOD1 induced adipocyte differentiation, whereas over-expression of MYOD1 inhibited adipogenesis. mRNA-seq showed that MYOD1 could perturb the lipid biosynthetic process during differentiation. Mechanistically, MYOD1 directly up-regulates the miR-206 expression by binding upstream 1200 bp region, and over-expression of miR-206 also inhibits adipogenesis. Furthermore, MYOD1 affected the expression of endogenous miR-206 and its target gene Kruppel Like Factor 4 (KLF4), which is an important activator of adipogenesis. Accordingly, the inhibition of miR-206 or over-expression of KLF4 could counteract the inhibitory effect of MYOD1 on adipocyte differentiation. Conclusions: These findings suggest that MYOD1 inhibited adipocyte differentiation by up-regulating miR-206 to suppress the KLF4 expression. Collectively, these findings identify a novel function of MYOD1 in adipocyte differentiation, suggesting a potential role in body-fat distribution regulation." @default.
- W4244611479 created "2022-05-12" @default.
- W4244611479 creator A5000858293 @default.
- W4244611479 creator A5010773610 @default.
- W4244611479 creator A5015739159 @default.
- W4244611479 creator A5052716698 @default.
- W4244611479 creator A5069486760 @default.
- W4244611479 creator A5070445053 @default.
- W4244611479 creator A5074516400 @default.
- W4244611479 creator A5077359852 @default.
- W4244611479 date "2020-11-19" @default.
- W4244611479 modified "2023-10-17" @default.
- W4244611479 title "MYOD1 Inhibits Avian Adipocyte Differentiation via miRNA-206/KLF4 Axis" @default.
- W4244611479 doi "https://doi.org/10.21203/rs.3.rs-107745/v1" @default.
- W4244611479 hasPublicationYear "2020" @default.
- W4244611479 type Work @default.
- W4244611479 citedByCount "0" @default.
- W4244611479 crossrefType "posted-content" @default.
- W4244611479 hasAuthorship W4244611479A5000858293 @default.
- W4244611479 hasAuthorship W4244611479A5010773610 @default.
- W4244611479 hasAuthorship W4244611479A5015739159 @default.
- W4244611479 hasAuthorship W4244611479A5052716698 @default.
- W4244611479 hasAuthorship W4244611479A5069486760 @default.
- W4244611479 hasAuthorship W4244611479A5070445053 @default.
- W4244611479 hasAuthorship W4244611479A5074516400 @default.
- W4244611479 hasAuthorship W4244611479A5077359852 @default.
- W4244611479 hasBestOaLocation W42446114791 @default.
- W4244611479 hasConcept C104317684 @default.
- W4244611479 hasConcept C122927707 @default.
- W4244611479 hasConcept C134018914 @default.
- W4244611479 hasConcept C148738053 @default.
- W4244611479 hasConcept C171089720 @default.
- W4244611479 hasConcept C198826908 @default.
- W4244611479 hasConcept C2776175234 @default.
- W4244611479 hasConcept C2777933648 @default.
- W4244611479 hasConcept C2778265714 @default.
- W4244611479 hasConcept C54355233 @default.
- W4244611479 hasConcept C86339819 @default.
- W4244611479 hasConcept C86803240 @default.
- W4244611479 hasConcept C95444343 @default.
- W4244611479 hasConceptScore W4244611479C104317684 @default.
- W4244611479 hasConceptScore W4244611479C122927707 @default.
- W4244611479 hasConceptScore W4244611479C134018914 @default.
- W4244611479 hasConceptScore W4244611479C148738053 @default.
- W4244611479 hasConceptScore W4244611479C171089720 @default.
- W4244611479 hasConceptScore W4244611479C198826908 @default.
- W4244611479 hasConceptScore W4244611479C2776175234 @default.
- W4244611479 hasConceptScore W4244611479C2777933648 @default.
- W4244611479 hasConceptScore W4244611479C2778265714 @default.
- W4244611479 hasConceptScore W4244611479C54355233 @default.
- W4244611479 hasConceptScore W4244611479C86339819 @default.
- W4244611479 hasConceptScore W4244611479C86803240 @default.
- W4244611479 hasConceptScore W4244611479C95444343 @default.
- W4244611479 hasLocation W42446114791 @default.
- W4244611479 hasOpenAccess W4244611479 @default.
- W4244611479 hasPrimaryLocation W42446114791 @default.
- W4244611479 hasRelatedWork W10105296 @default.
- W4244611479 hasRelatedWork W11195820 @default.
- W4244611479 hasRelatedWork W23455185 @default.
- W4244611479 hasRelatedWork W25551312 @default.
- W4244611479 hasRelatedWork W29570062 @default.
- W4244611479 hasRelatedWork W29967429 @default.
- W4244611479 hasRelatedWork W31347067 @default.
- W4244611479 hasRelatedWork W35163240 @default.
- W4244611479 hasRelatedWork W39506567 @default.
- W4244611479 hasRelatedWork W22776812 @default.
- W4244611479 isParatext "false" @default.
- W4244611479 isRetracted "false" @default.
- W4244611479 workType "article" @default.