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- W4244642719 abstract "During navigation, grid cells increase their spike rates in firing fields arranged on a markedly regular triangular lattice, whereas their spike timing is often modulated by theta oscillations. Oscillatory interference models of grid cells predict theta amplitude modulations of membrane potential during firing field traversals, whereas competing attractor network models predict slow depolarizing ramps. Here, using in vivo whole-cell recordings, we tested these models by directly measuring grid cell intracellular potentials in mice running along linear tracks in virtual reality. Grid cells had large and reproducible ramps of membrane potential depolarization that were the characteristic signature tightly correlated with firing fields. Grid cells also demonstrated intracellular theta oscillations that influenced their spike timing. However, the properties of theta amplitude modulations were not consistent with the view that they determine firing field locations. Our results support cellular and network mechanisms in which grid fields are produced by slow ramps, as in attractor models, whereas theta oscillations control spike timing. PMID: 23395984 Funding information This work was supported by: NINDS NIH HHS, United States Grant ID: R37 NS081242 NINDS NIH HHS, United States Grant ID: 5RC1NS068148-02 NINDS NIH HHS, United States Grant ID: F32NS070514-01A1 NINDS NIH HHS, United States Grant ID: 1R37NS081242-01 NINDS NIH HHS, United States Grant ID: RC1 NS068148 NIMH NIH HHS, United States Grant ID: R01 MH083686 NINDS NIH HHS, United States Grant ID: F32 NS070514 NIMH NIH HHS, United States Grant ID: 5R01MH083686-04 More Less keyboard_arrow_down" @default.
- W4244642719 created "2022-05-12" @default.
- W4244642719 creator A5003799567 @default.
- W4244642719 creator A5041075627 @default.
- W4244642719 date "2013-05-08" @default.
- W4244642719 modified "2023-09-28" @default.
- W4244642719 title "Faculty Opinions recommendation of Membrane potential dynamics of grid cells." @default.
- W4244642719 doi "https://doi.org/10.3410/f.717977299.793476138" @default.
- W4244642719 hasPublicationYear "2013" @default.
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