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- W4244655944 abstract "A cell-adhesive protein of the human serum, 90K binds galactin-3, β1-integrins, collagens, and fibronectin, and it is of importance in cell-cell and cell–extracellular matrix adhesion. Serum 90K levels in 137 patients with lymphoma were measured by enzyme-linked immunosorbent assay. Compared with healthy controls, pretreatment serum 90K levels in patients with lymphoma were elevated (P < .001). Of 97 patients who showed objective response to treatment, 20 (21%) had pretreatment 90K levels above the normal cutoff compared with 17 (53%) of 32 patients who did not respond (P = .002). When used as a plastic-immobilized substrate, 90K caused a significant reduction in chemotherapy-induced apoptosis of Jurkat T lymphoma cells. This finding could explain the lack of response in lymphoma patients with high 90K serum levels." @default.
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- W4244655944 date "2000-11-01" @default.
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- W4244655944 title "Adhesion to 90K (Mac-2 BP) as a mechanism for lymphoma drug resistance in vivo" @default.
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- W4244655944 doi "https://doi.org/10.1182/blood.v96.9.3282.h8003282_3282_3285" @default.
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