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- W4244656558 abstract "Azathioprine is a synthetic purine analogue — the 1-methyl-4-nitro-5-imidazolyl derivative of thioguanine. The principal metabolite of azathioprine is 6-mercaptopurine and this is metabolised by hypoxanthine guanine phosphoribosyl transferase (HGPRT) to produce the active metabolites thioinosinic and thioguanylic acid. These metabolites inhibit intracellular function by interfering with adenine and guanine ribonucleotide production through suppression of inosinic acid synthesis [1]. These effects result in downregulation of actively proliferating cells with a particular effect on bone marrow." @default.
- W4244656558 created "2022-05-12" @default.
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- W4244656558 date "2005-01-01" @default.
- W4244656558 modified "2023-09-29" @default.
- W4244656558 title "Azathioprine" @default.
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- W4244656558 doi "https://doi.org/10.1007/978-3-7643-7726-7_8" @default.
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