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- W4244682118 abstract "The cells of solid tumors, in contrast to those of leukemia, exist for most of their life-span outside the blood stream or bone marrow. Such tumor cells grow in densely packed populations that develop into spheroid or ellipsoid aggregates. Neovascularization is an event that separates the development of any solid tumor into two stages: the avascular stage and the vascular stage. Because of this angiogenesis plays a critical role in the biology of solid neoplasms. The two stages can be dissociated under experimental conditions. When this is accomplished and capillaries are prevented from penetrating the l-mm tumor, the tumor becomes dormant. The possibility exists that solid tumors can display their full malignant potential only after they have elicited new vascular channels from the host for their own use. If this vascular growth could be prevented by interrupting the tumor signal that triggers capillary proliferation, then small tumor populations—dependent upon the same principles of diffusion for the absorption of nutrients and release of catabolites as normal cells—should remain dormant. This approach can be called “antiangiogenesis.” If it can be achieved it may become a potent therapy in its own right or be a powerful adjunct to other methods of treatment. The careful exploration of its consequences can help in understanding many fundamental aspects of the nature of growing cells in packed population in vivo, and in illuminating the mechanisms of vascularization." @default.
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- W4244682118 creator A5088978035 @default.
- W4244682118 date "1974-01-01" @default.
- W4244682118 modified "2023-10-17" @default.
- W4244682118 title "Tumor Angiogenesis" @default.
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- W4244682118 doi "https://doi.org/10.1016/s0065-230x(08)60058-5" @default.
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