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- W4244684461 abstract "Nitric oxide (NO) is a possible agent, which induces crosslinking among molecules containing sulfhydryl groups. However, the S-thiolation is essentially accompanied by S-nitrosylation. In the present study, we evaluated radical scavengers as a regulator for S-thiolation and S-nitrosylation by NO released from NO-generator, 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-1-triazene (P-NONOate). When glutathione was incubated with P-NONOate in 4% (vol/vol) O2-saturated buffer solution (pH 7.4) in the presence of nitrone spin-trapping agent, 5,5′-dimethyl-1-pyroline-N-oxide (DMPO), the prevention of S-thiolation and the promotion of S-nitrosylation were observed. The DMPO adduct was identified to be thiyl radical–DMPO adduct via ESR study. In contrast, nitroxyl radical, radical scavenger against oxygen-centered radicals, promoted the S-thiolation but prevented S-nitrosylation. Nitronyl nitroxide, radical scavenger against nitric oxide, can convert nitric oxide into nitrogen dioxide in the O2-independent manner. In the presence of nitronyl nitroxide in the thiol/P-NONOate system, S-thiolation was remarkably enhanced up to 60% (mol/mol) of sulfhydryl groups. However, nitronyl nitroxide at enough content (⩾1.0 mM) almost completely prevented S-nitrosylation, whereas nitronyl nitroxide at comparatively lower content (0.5 mM) contrarily enhanced the S-nitrosylation. Based on these facts, it appeared to be possible to consequently regulate S-thiolation and S-nitrosylation through controlling the thiyl radical chain reaction by radical scavengers." @default.
- W4244684461 created "2022-05-12" @default.
- W4244684461 date "1999-01-01" @default.
- W4244684461 modified "2023-09-26" @default.
- W4244684461 title "Porphyrin-based SOD mimics. Electrospray mass spectroscopy of Mn(III) and Fe(III) isomeric tetrakis-(N-alkylpyridyl) porphyrins" @default.
- W4244684461 doi "https://doi.org/10.1016/s0891-5849(99)90550-6" @default.
- W4244684461 hasPublicationYear "1999" @default.
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