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• W4244736186 endingPage "11995" @default.
• W4244736186 startingPage "11992" @default.
• W4244736186 abstract "Cyclopropanes fused to pyrrolidines are important structural features found in a number of marketed drugs and development candidates. Typically, their synthesis involves the cyclopropanation of a dihydropyrrole precursor. Reported herein is a complementary approach which employs a palladium(0)-catalyzed CH functionalization of an achiral cyclopropane to close the pyrrolidine ring in an enantioselective manner. In contrast to aryl–aryl couplings, palladium(0)-catalyzed CH functionalizations involving the formation of C(sp3)C(sp3) bonds of saturated heterocycles are very scarce. The presented strategy yields cyclopropane-fused γ-lactams from chloroacetamide substrates. A bulky Taddol phosphonite ligand in combination with adamantane-1-carboxylic acid as a cocatalyst provides the γ-lactams in excellent yields and enantioselectivities." @default.
• W4244736186 created "2022-05-12" @default.
• W4244736186 creator A5018021290 @default.
• W4244736186 creator A5077111123 @default.
• W4244736186 date "2015-08-12" @default.
• W4244736186 modified "2023-10-01" @default.
• W4244736186 title "Chiral γ-Lactams by Enantioselective Palladium(0)-Catalyzed Cyclopropane Functionalizations" @default.
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• W4244736186 doi "https://doi.org/10.1002/ange.201505916" @default.
• W4244736186 hasPublicationYear "2015" @default.
• W4244736186 type Work @default.
• W4244736186 citedByCount "58" @default.

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