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- W4244772015 abstract "We agree with Dr. Brosens that performing a second-look laparoscopy with biopsy is not the only way to evaluate the response of endometriosis to medical treatment. That is why we evaluated pain daily and reported the change in pain scores as a primary outcome of this study (1Ailawadi R.K Jobanputra S Kataria M Gurates B Bulun S.E Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate a pilot study.Fertil Steril. 2004; 81: 290-296Abstract Full Text Full Text PDF PubMed Scopus (199) Google Scholar). Because we introduced a novel treatment of endometriosis, we attempted to evaluate the outcome from as many different angles as possible. These included initial and second-look laparoscopies with biopsies and daily pain scores. Laparoscopy with biopsy does have limitations; however, a referral to this procedure as a “visual illusion” should at best be considered an eccentric point of view not shared by the majority of gynecologists. We clearly indicated in the article that patients with endometriomas or other ovarian cysts were excluded (1Ailawadi R.K Jobanputra S Kataria M Gurates B Bulun S.E Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate a pilot study.Fertil Steril. 2004; 81: 290-296Abstract Full Text Full Text PDF PubMed Scopus (199) Google Scholar). Therefore, the criticisms related to endometriomas or hemorrhagic cysts do not pertain. We did not claim in the article that this new regimen provided a cure or prevented recurrences. We demonstrated a very effective treatment that suppressed endometriosis not responding to existing medical or surgical ablative measures. Therefore, we were satisfied to observe that pain significantly decreased during and immediately after the treatment. Finally, we included the term “…: a pilot study” in the title for a reason: this study represents the first report of the use of letrozole in the treatment of endometriosis. The points that Dr. Brosens has brought up should be considered by investigators who will design future clinical trials of aromatase inhibitors in the treatment of endometriosis." @default.
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- W4244772015 date "2004-07-01" @default.
- W4244772015 modified "2023-09-28" @default.
- W4244772015 title "Reply of the Author" @default.
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- W4244772015 doi "https://doi.org/10.1016/j.fertnstert.2004.04.009" @default.
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