Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244844077> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4244844077 endingPage "357a" @default.
- W4244844077 startingPage "357a" @default.
- W4244844077 abstract "Vitamin A homeostasis is key to cellular function and human physiology. The integral membrane receptor STRA6 mediates tissue uptake of vitamin A through recognition of the retinol-binding protein-retinol complex. STRA6 acts as a transporter, but it has alternatively been suggested to function in transmembrane signaling. Here we present the structure of STRA6 determined to 3.9Å resolution by single-particle cryo-electron microscopy. STRA6 is a dimer, in which each protomer contributes nine transmembrane and a central horizontal intramembrane helix that is positioned at the core of the dimer interface. Surprisingly, the C-terminus of each protomer is tightly bound to calmodulin in a noncanonical arrangement. The structure suggests alternate modes for internalization of retinol, and provides a template to further investigate the physiological role of STRA6." @default.
- W4244844077 created "2022-05-12" @default.
- W4244844077 creator A5008587611 @default.
- W4244844077 date "2017-02-01" @default.
- W4244844077 modified "2023-09-30" @default.
- W4244844077 title "Structure of the STRA6 Receptor for Retinol Uptake" @default.
- W4244844077 doi "https://doi.org/10.1016/j.bpj.2016.11.1934" @default.
- W4244844077 hasPublicationYear "2017" @default.
- W4244844077 type Work @default.
- W4244844077 citedByCount "0" @default.
- W4244844077 crossrefType "journal-article" @default.
- W4244844077 hasAuthorship W4244844077A5008587611 @default.
- W4244844077 hasBestOaLocation W42448440771 @default.
- W4244844077 hasConcept C118892022 @default.
- W4244844077 hasConcept C12554922 @default.
- W4244844077 hasConcept C139770010 @default.
- W4244844077 hasConcept C14036430 @default.
- W4244844077 hasConcept C170493617 @default.
- W4244844077 hasConcept C178790620 @default.
- W4244844077 hasConcept C185592680 @default.
- W4244844077 hasConcept C24530287 @default.
- W4244844077 hasConcept C2776940978 @default.
- W4244844077 hasConcept C2779546866 @default.
- W4244844077 hasConcept C2779573558 @default.
- W4244844077 hasConcept C47701112 @default.
- W4244844077 hasConcept C55493867 @default.
- W4244844077 hasConcept C57581600 @default.
- W4244844077 hasConcept C86803240 @default.
- W4244844077 hasConcept C95444343 @default.
- W4244844077 hasConcept C97749175 @default.
- W4244844077 hasConceptScore W4244844077C118892022 @default.
- W4244844077 hasConceptScore W4244844077C12554922 @default.
- W4244844077 hasConceptScore W4244844077C139770010 @default.
- W4244844077 hasConceptScore W4244844077C14036430 @default.
- W4244844077 hasConceptScore W4244844077C170493617 @default.
- W4244844077 hasConceptScore W4244844077C178790620 @default.
- W4244844077 hasConceptScore W4244844077C185592680 @default.
- W4244844077 hasConceptScore W4244844077C24530287 @default.
- W4244844077 hasConceptScore W4244844077C2776940978 @default.
- W4244844077 hasConceptScore W4244844077C2779546866 @default.
- W4244844077 hasConceptScore W4244844077C2779573558 @default.
- W4244844077 hasConceptScore W4244844077C47701112 @default.
- W4244844077 hasConceptScore W4244844077C55493867 @default.
- W4244844077 hasConceptScore W4244844077C57581600 @default.
- W4244844077 hasConceptScore W4244844077C86803240 @default.
- W4244844077 hasConceptScore W4244844077C95444343 @default.
- W4244844077 hasConceptScore W4244844077C97749175 @default.
- W4244844077 hasIssue "3" @default.
- W4244844077 hasLocation W42448440771 @default.
- W4244844077 hasOpenAccess W4244844077 @default.
- W4244844077 hasPrimaryLocation W42448440771 @default.
- W4244844077 hasRelatedWork W1991747582 @default.
- W4244844077 hasRelatedWork W2016573390 @default.
- W4244844077 hasRelatedWork W2037774298 @default.
- W4244844077 hasRelatedWork W2038134454 @default.
- W4244844077 hasRelatedWork W2038141086 @default.
- W4244844077 hasRelatedWork W2052717398 @default.
- W4244844077 hasRelatedWork W2073439477 @default.
- W4244844077 hasRelatedWork W2078560293 @default.
- W4244844077 hasRelatedWork W2085451374 @default.
- W4244844077 hasRelatedWork W3005112620 @default.
- W4244844077 hasVolume "112" @default.
- W4244844077 isParatext "false" @default.
- W4244844077 isRetracted "false" @default.
- W4244844077 workType "article" @default.