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- W4244906949 abstract "Although successful visualization of amyloid deposits in the APP transgenic mouse brain with MR imaging has been reported recently, there is no suitable method to measure plaque load (PL). We present a novel method based on simulated flooding (watersheds) to segment amyloid plaques in mouse brain images. In this method, the image is segmented into catchment basins (CB) associated with local minima and CBs that correspond to plaques are selected using the data Laplacian as a feature describing local variation. Besides PL (volume fraction) estimation, our method can be also used to analyze other plaque characteristics such as size, shape and distribution. The automatic plaque segmentation algorithm has two steps: First, simulated flooding is used to extract regions with low intensities completely surrounded by higher intensity neighbors. The resulting map defines the CBs of the MR local minima. Second, the image Laplacian L(I) = div (grad (I)) is used to model the plaque cores, defined as regions with small derivatives, surrounded by rapidly increasing neighbors. Plaques are segmented by taking the CBs that have maximum Laplacians larger than the background noise. The algorithm was used to compute PL in the subiculum of 2 and 10 months old 5XFAD APP/PS1 transgenic mice. RARE 3D-images of fixed brains acquired on a 14.1T microimager using TR/TEeff 2500ms/40ms and pixel size 35μm x35μm x35μm were analyzed. The algorithm was applied to histology data from the same brains and PL results were compared for validation. The computed PL values increased with age for the 5XFAD mice from 1.25% at 2 months to 25.0% at 10 months. A non-transgenic control mouse had a PL of nearly 0% as expected. Our results are consistent with the known evolution of plaque deposition in this strain. Amyloid plaques begin to appear in the subiculum of 2 month old 5XFAD mice and by 10 months of age numerous plaques are found in subiculum, hippocampus and deep layers of the cortex. Our automatic computational method for the quantitation of plaques can be applied to evaluate disease progression and efficacy of therapy in transgenic mouse models of AD." @default.
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- W4244906949 date "2008-07-01" @default.
- W4244906949 modified "2023-09-27" @default.
- W4244906949 title "P2-021: A method to quantitate amyloid plaque load in a transgenic mouse model of Alzheimer's disease" @default.
- W4244906949 doi "https://doi.org/10.1016/j.jalz.2008.05.1101" @default.
- W4244906949 hasPublicationYear "2008" @default.
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