Matches in SemOpenAlex for { <https://semopenalex.org/work/W4244941904> ?p ?o ?g. }
- W4244941904 endingPage "181" @default.
- W4244941904 startingPage "176" @default.
- W4244941904 abstract "Objectives: TNF-α and IL-2 are important cytokines in macrophage and T-lymphocyte activity against infection and dissemination of malignant cells. We studied the influence of supernatants from stored whole blood and buffy-coat-depleted SAGM (saline, adenine, glucose and mannitol) blood in stimulating TNF-α and IL-2 release in an ex vivo assay. Methods: Supernatants of 10 units of whole blood and 10 units of SAGM blood were collected after 1, 21 and 35 days of standard blood bank storage. Heparinized blood from 20 healthy volunteers (as ‘recipients’), corresponding in ABO and Rh type to the stored blood, were used in a culture system with LPS and PHA as stimulators of TNF-α and IL-2 release. The effect of added supernatants, from either stored whole blood or SAGM blood, on cytokine release was evaluated compared to saline as control. TNF-α concentration was analyzed by ELISA after culture for 24 h and IL-2 after 72 h, respectively. Results: Supernatants from both stored whole blood and SAGM blood showed a significant decrease in both LPS- and PHA-stimulated TNF-α release that was dependent on storage time. IL-2 was not detected in response to LPS stimulation. PHA-stimulated IL-2 release was significantly reduced and related to storage time of both whole blood and SAGM blood. Conclusions: Recipient cytokine release induced by blood transfusion seems to be dependent on storage time. This may have implications in transfusion-induced immune modulation." @default.
- W4244941904 created "2022-05-12" @default.
- W4244941904 creator A5034338817 @default.
- W4244941904 creator A5065405638 @default.
- W4244941904 creator A5067589745 @default.
- W4244941904 creator A5080825465 @default.
- W4244941904 date "1998-04-01" @default.
- W4244941904 modified "2023-10-18" @default.
- W4244941904 title "Immunomodulating Effect of Blood Transfusion: Is Storage Time Important?" @default.
- W4244941904 cites W106976724 @default.
- W4244941904 cites W1565524838 @default.
- W4244941904 cites W1984253491 @default.
- W4244941904 cites W1990900255 @default.
- W4244941904 cites W1992148976 @default.
- W4244941904 cites W1996634816 @default.
- W4244941904 cites W2019913619 @default.
- W4244941904 cites W2020710072 @default.
- W4244941904 cites W2023480611 @default.
- W4244941904 cites W2028024229 @default.
- W4244941904 cites W2031803221 @default.
- W4244941904 cites W2037099335 @default.
- W4244941904 cites W2037194467 @default.
- W4244941904 cites W2040880503 @default.
- W4244941904 cites W2056446998 @default.
- W4244941904 cites W2059202294 @default.
- W4244941904 cites W2060434000 @default.
- W4244941904 cites W2072729552 @default.
- W4244941904 cites W2082308378 @default.
- W4244941904 cites W2090597226 @default.
- W4244941904 cites W2093198834 @default.
- W4244941904 cites W2105699050 @default.
- W4244941904 cites W2109456953 @default.
- W4244941904 cites W2110377345 @default.
- W4244941904 cites W2125767445 @default.
- W4244941904 cites W2146347312 @default.
- W4244941904 cites W2164008735 @default.
- W4244941904 cites W2295367859 @default.
- W4244941904 cites W2406699269 @default.
- W4244941904 cites W2464369334 @default.
- W4244941904 cites W2793178146 @default.
- W4244941904 cites W4231274077 @default.
- W4244941904 cites W4298413429 @default.
- W4244941904 doi "https://doi.org/10.1046/j.1423-0410.1998.7430176.x" @default.
- W4244941904 hasPublicationYear "1998" @default.
- W4244941904 type Work @default.
- W4244941904 citedByCount "38" @default.
- W4244941904 countsByYear W42449419042012 @default.
- W4244941904 countsByYear W42449419042016 @default.
- W4244941904 countsByYear W42449419042023 @default.
- W4244941904 crossrefType "journal-article" @default.
- W4244941904 hasAuthorship W4244941904A5034338817 @default.
- W4244941904 hasAuthorship W4244941904A5065405638 @default.
- W4244941904 hasAuthorship W4244941904A5067589745 @default.
- W4244941904 hasAuthorship W4244941904A5080825465 @default.
- W4244941904 hasConcept C126322002 @default.
- W4244941904 hasConcept C1621761 @default.
- W4244941904 hasConcept C16685009 @default.
- W4244941904 hasConcept C176080213 @default.
- W4244941904 hasConcept C185592680 @default.
- W4244941904 hasConcept C202751555 @default.
- W4244941904 hasConcept C203014093 @default.
- W4244941904 hasConcept C26291073 @default.
- W4244941904 hasConcept C2777397205 @default.
- W4244941904 hasConcept C2778285947 @default.
- W4244941904 hasConcept C2778690821 @default.
- W4244941904 hasConcept C2779979121 @default.
- W4244941904 hasConcept C2780014101 @default.
- W4244941904 hasConcept C2994072243 @default.
- W4244941904 hasConcept C545542383 @default.
- W4244941904 hasConcept C55493867 @default.
- W4244941904 hasConcept C71924100 @default.
- W4244941904 hasConcept C8891405 @default.
- W4244941904 hasConceptScore W4244941904C126322002 @default.
- W4244941904 hasConceptScore W4244941904C1621761 @default.
- W4244941904 hasConceptScore W4244941904C16685009 @default.
- W4244941904 hasConceptScore W4244941904C176080213 @default.
- W4244941904 hasConceptScore W4244941904C185592680 @default.
- W4244941904 hasConceptScore W4244941904C202751555 @default.
- W4244941904 hasConceptScore W4244941904C203014093 @default.
- W4244941904 hasConceptScore W4244941904C26291073 @default.
- W4244941904 hasConceptScore W4244941904C2777397205 @default.
- W4244941904 hasConceptScore W4244941904C2778285947 @default.
- W4244941904 hasConceptScore W4244941904C2778690821 @default.
- W4244941904 hasConceptScore W4244941904C2779979121 @default.
- W4244941904 hasConceptScore W4244941904C2780014101 @default.
- W4244941904 hasConceptScore W4244941904C2994072243 @default.
- W4244941904 hasConceptScore W4244941904C545542383 @default.
- W4244941904 hasConceptScore W4244941904C55493867 @default.
- W4244941904 hasConceptScore W4244941904C71924100 @default.
- W4244941904 hasConceptScore W4244941904C8891405 @default.
- W4244941904 hasIssue "3" @default.
- W4244941904 hasLocation W42449419041 @default.
- W4244941904 hasOpenAccess W4244941904 @default.
- W4244941904 hasPrimaryLocation W42449419041 @default.
- W4244941904 hasRelatedWork W1820832512 @default.
- W4244941904 hasRelatedWork W2047209980 @default.
- W4244941904 hasRelatedWork W2055868288 @default.
- W4244941904 hasRelatedWork W2068366672 @default.