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- W4244964808 endingPage "54" @default.
- W4244964808 startingPage "45" @default.
- W4244964808 abstract "In her early studies of group A streptococci (Streptococcus pyogenes), Rebecca Lancefield noted an association between virulence and a distinctive appearance of the bacterial colonies on solid media. Isolates that were highly virulent for mice and that grew well in fresh human blood typically formed large colonies with a translucent, liquid appearance (mucoid) or an irregular, collapsed appearance (matte). By contrast, avirulent isolates that grew poorly in human blood formed compact, opaque colonies (glossy). Strains that grew as mucoid or matte colonies usually produced large amounts of M protein, which Lancefield gave the designation “M” because of this association with colony morphology (1, 2). Later work by Armine Wilson demonstrated that the mucoid or matte appearance of such strains was in fact due to elaboration of capsular polysaccharide, not M protein (3). Wilson showed that the mucoid or matte colony type was converted to a nonmucoid or glossy colony by growth on medium containing hyaluronidase which digested the hyaluronic acid capsule, whereas growth on medium containing trypsin, which digested M protein, had no such effect. Furthermore, while many strains that produced abundant capsular polysaccharide also were rich in M protein, expression of the two surface products was not always linked; certain mucoid or highly encapsulated strains produced little or no M protein, and certain strains rich in M protein produced little or no capsule (1, 4)." @default.
- W4244964808 created "2022-05-12" @default.
- W4244964808 creator A5086156918 @default.
- W4244964808 date "2019-11-26" @default.
- W4244964808 modified "2023-10-14" @default.
- W4244964808 title "Capsular Polysaccharide of Group A<i>Streptococcus</i>" @default.
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