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- W4244965362 abstract "Abstract The lomaiviticins and kinamycins are complex DNA damaging natural products that contain a diazofluorene functional group. Herein, we elucidate the influence of skeleton structure, ring and chain isomerization, D‐ring oxidation state, and naphthoquinone substitution on DNA binding and damaging activity. We show that the electrophilicity of the diazofluorene appears to be a significant determinant of DNA damaging activity. These studies identify the monomeric diazofluorene 11 as a potent DNA cleavage agent in tissue culture. The simpler structure of 11 relative to the natural products establishes it as a useful lead for translational studies." @default.
- W4244965362 created "2022-05-12" @default.
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- W4244965362 date "2014-07-09" @default.
- W4244965362 modified "2023-10-18" @default.
- W4244965362 title "Analysis of Diazofluorene DNA Binding and Damaging Activity: DNA Cleavage by a Synthetic Monomeric Diazofluorene" @default.
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- W4244965362 doi "https://doi.org/10.1002/ange.201404137" @default.
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