Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245024231> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4245024231 endingPage "1158" @default.
- W4245024231 startingPage "1153" @default.
- W4245024231 abstract "The polyamines putrescine, spermidine, and spermine have been implicated in the regulation of cell proliferation and differentiation. Previous studies, however, have demonstrated that the polyamines are essential for proliferation, but not differentiation, of HL-60 human promyelocytic leukemia cells. We have extended these findings by demonstrating a highly significant relationship between intracellular spermidine levels and HL-60 proliferation. However, in contrast to previous studies, we have also demonstrated that induction of HL-60 differentiation with dimethyl sulfoxide, hexamethylene bisacetamide, butyric acid, or retinoic acid is inhibited by alpha-difluoromethyl ornithine (DFMO) depletion of intracellular putrescine and spermidine. Further, the addition of exogenous spermidine abrogates DFMO inhibition of HL-60 differentiation, thus confirming the involvement of this polyamine in the expression of a differentiated phenotype. The discrepancy between our results and those of previous studies probably stems from the nearly complete, rather than partial, depletion of intracellular spermidine achieved in the present work. The results of the present study thus demonstrate the involvement of spermidine in both proliferation and induction of HL-60 differentiation with certain agents." @default.
- W4245024231 created "2022-05-12" @default.
- W4245024231 creator A5040576337 @default.
- W4245024231 creator A5050354040 @default.
- W4245024231 creator A5073743214 @default.
- W4245024231 creator A5086091315 @default.
- W4245024231 creator A5089142180 @default.
- W4245024231 date "1984-05-01" @default.
- W4245024231 modified "2023-10-16" @default.
- W4245024231 title "Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells" @default.
- W4245024231 doi "https://doi.org/10.1182/blood.v63.5.1153.bloodjournal6351153" @default.
- W4245024231 hasPublicationYear "1984" @default.
- W4245024231 type Work @default.
- W4245024231 citedByCount "1" @default.
- W4245024231 crossrefType "journal-article" @default.
- W4245024231 hasAuthorship W4245024231A5040576337 @default.
- W4245024231 hasAuthorship W4245024231A5050354040 @default.
- W4245024231 hasAuthorship W4245024231A5073743214 @default.
- W4245024231 hasAuthorship W4245024231A5086091315 @default.
- W4245024231 hasAuthorship W4245024231A5089142180 @default.
- W4245024231 hasBestOaLocation W42450242311 @default.
- W4245024231 hasConcept C104317684 @default.
- W4245024231 hasConcept C148738053 @default.
- W4245024231 hasConcept C181199279 @default.
- W4245024231 hasConcept C2776109719 @default.
- W4245024231 hasConcept C2776601000 @default.
- W4245024231 hasConcept C2777167505 @default.
- W4245024231 hasConcept C2777497464 @default.
- W4245024231 hasConcept C2779982571 @default.
- W4245024231 hasConcept C2780115381 @default.
- W4245024231 hasConcept C2781121885 @default.
- W4245024231 hasConcept C55493867 @default.
- W4245024231 hasConcept C62112901 @default.
- W4245024231 hasConcept C79879829 @default.
- W4245024231 hasConcept C86803240 @default.
- W4245024231 hasConcept C95444343 @default.
- W4245024231 hasConceptScore W4245024231C104317684 @default.
- W4245024231 hasConceptScore W4245024231C148738053 @default.
- W4245024231 hasConceptScore W4245024231C181199279 @default.
- W4245024231 hasConceptScore W4245024231C2776109719 @default.
- W4245024231 hasConceptScore W4245024231C2776601000 @default.
- W4245024231 hasConceptScore W4245024231C2777167505 @default.
- W4245024231 hasConceptScore W4245024231C2777497464 @default.
- W4245024231 hasConceptScore W4245024231C2779982571 @default.
- W4245024231 hasConceptScore W4245024231C2780115381 @default.
- W4245024231 hasConceptScore W4245024231C2781121885 @default.
- W4245024231 hasConceptScore W4245024231C55493867 @default.
- W4245024231 hasConceptScore W4245024231C62112901 @default.
- W4245024231 hasConceptScore W4245024231C79879829 @default.
- W4245024231 hasConceptScore W4245024231C86803240 @default.
- W4245024231 hasConceptScore W4245024231C95444343 @default.
- W4245024231 hasIssue "5" @default.
- W4245024231 hasLocation W42450242311 @default.
- W4245024231 hasOpenAccess W4245024231 @default.
- W4245024231 hasPrimaryLocation W42450242311 @default.
- W4245024231 hasRelatedWork W194067 @default.
- W4245024231 hasRelatedWork W2469834 @default.
- W4245024231 hasRelatedWork W25715796 @default.
- W4245024231 hasRelatedWork W2648554 @default.
- W4245024231 hasRelatedWork W32813384 @default.
- W4245024231 hasRelatedWork W32924657 @default.
- W4245024231 hasRelatedWork W33353942 @default.
- W4245024231 hasRelatedWork W41807374 @default.
- W4245024231 hasRelatedWork W44051562 @default.
- W4245024231 hasRelatedWork W8777225 @default.
- W4245024231 hasVolume "63" @default.
- W4245024231 isParatext "false" @default.
- W4245024231 isRetracted "false" @default.
- W4245024231 workType "article" @default.