Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245069686> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4245069686 abstract "Abstract Background: This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement release system with different concentrations of enoxaparin sodium (ES) and to investigate the release characteristics of ES after loading into the PMMA bone cement. Methods: In the experimental group, 40g Palacos®R PMMA bone cement was loaded with various amount of ES 4000, 8000, 12000, 16000, 20000, and 24000 AXaIU, respectively. The control group was not loaded with ES. Scanning electron microscopy (SEM) was used to observe the surface microstructure of the bone cement in the two groups. In the experiment group, the mold was extracted continuously with pH7.4 Tris-HCL buffer for 10 days. The extract solution was collected every day and the anti-FXa potency was measured. The experiment design and statistical analysis were conducted using a quantitative response parallel line method. Results: Under the SEM, it was observed that ES was filled in the pores of PMMA bone cement polymer structure and released from the pores after extraction. There was a burst effect of the release. The release amount of ES on the first day was 0.415, 0.858, 1.110, 1.564, 1.952 and 2.513 respectively from the six groups with various ES loading amount of 4000, 8000, 12000, 16000, 20000 and 24000 AXaIU, all reaching the peak of release on the first day. The release decreased rapidly on the next day and entered the plateau phase on the fourth day. Conclusion: PMMA bone cement can be used as a carrier to effectively release enoxaparin sodium within a short term." @default.
- W4245069686 created "2022-05-12" @default.
- W4245069686 creator A5018363202 @default.
- W4245069686 creator A5032001213 @default.
- W4245069686 creator A5046597133 @default.
- W4245069686 creator A5049328355 @default.
- W4245069686 creator A5074290483 @default.
- W4245069686 creator A5081134571 @default.
- W4245069686 date "2020-11-05" @default.
- W4245069686 modified "2023-09-29" @default.
- W4245069686 title "Release Characteristics of Enoxaparin Sodium Loaded Polymethylmethacrylate Bone Cement" @default.
- W4245069686 doi "https://doi.org/10.21203/rs.3.rs-101442/v1" @default.
- W4245069686 hasPublicationYear "2020" @default.
- W4245069686 type Work @default.
- W4245069686 citedByCount "0" @default.
- W4245069686 crossrefType "posted-content" @default.
- W4245069686 hasAuthorship W4245069686A5018363202 @default.
- W4245069686 hasAuthorship W4245069686A5032001213 @default.
- W4245069686 hasAuthorship W4245069686A5046597133 @default.
- W4245069686 hasAuthorship W4245069686A5049328355 @default.
- W4245069686 hasAuthorship W4245069686A5074290483 @default.
- W4245069686 hasAuthorship W4245069686A5081134571 @default.
- W4245069686 hasBestOaLocation W42450696861 @default.
- W4245069686 hasConcept C136229726 @default.
- W4245069686 hasConcept C159985019 @default.
- W4245069686 hasConcept C185592680 @default.
- W4245069686 hasConcept C191897082 @default.
- W4245069686 hasConcept C192562407 @default.
- W4245069686 hasConcept C26771246 @default.
- W4245069686 hasConcept C2778891590 @default.
- W4245069686 hasConcept C43617362 @default.
- W4245069686 hasConcept C4725764 @default.
- W4245069686 hasConcept C521977710 @default.
- W4245069686 hasConcept C523993062 @default.
- W4245069686 hasConcept C537181965 @default.
- W4245069686 hasConcept C71924100 @default.
- W4245069686 hasConcept C87976508 @default.
- W4245069686 hasConceptScore W4245069686C136229726 @default.
- W4245069686 hasConceptScore W4245069686C159985019 @default.
- W4245069686 hasConceptScore W4245069686C185592680 @default.
- W4245069686 hasConceptScore W4245069686C191897082 @default.
- W4245069686 hasConceptScore W4245069686C192562407 @default.
- W4245069686 hasConceptScore W4245069686C26771246 @default.
- W4245069686 hasConceptScore W4245069686C2778891590 @default.
- W4245069686 hasConceptScore W4245069686C43617362 @default.
- W4245069686 hasConceptScore W4245069686C4725764 @default.
- W4245069686 hasConceptScore W4245069686C521977710 @default.
- W4245069686 hasConceptScore W4245069686C523993062 @default.
- W4245069686 hasConceptScore W4245069686C537181965 @default.
- W4245069686 hasConceptScore W4245069686C71924100 @default.
- W4245069686 hasConceptScore W4245069686C87976508 @default.
- W4245069686 hasLocation W42450696861 @default.
- W4245069686 hasLocation W42450696862 @default.
- W4245069686 hasLocation W42450696863 @default.
- W4245069686 hasOpenAccess W4245069686 @default.
- W4245069686 hasPrimaryLocation W42450696861 @default.
- W4245069686 hasRelatedWork W1530548 @default.
- W4245069686 hasRelatedWork W21257819 @default.
- W4245069686 hasRelatedWork W22885034 @default.
- W4245069686 hasRelatedWork W23584932 @default.
- W4245069686 hasRelatedWork W24272175 @default.
- W4245069686 hasRelatedWork W24457575 @default.
- W4245069686 hasRelatedWork W5780337 @default.
- W4245069686 hasRelatedWork W8553179 @default.
- W4245069686 hasRelatedWork W9364796 @default.
- W4245069686 hasRelatedWork W6683565 @default.
- W4245069686 isParatext "false" @default.
- W4245069686 isRetracted "false" @default.
- W4245069686 workType "article" @default.