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- W4245199033 abstract "N-Acetyltransferases (NAT) are important determinants of the metabolic fate of numerous environmental and pharmaceutical arylamines. Disposition of these aromatic nitrogen substrates has significant effects on their interaction with the organism including activation and detoxification of carcinogenic properties, efficacy and toxicity of therapeutic potential, and regulation of fetal development. Any compound containing an arylamine moiety, or which can be biotransformed to expose or produce such moiety, must be considered a potential substrate for acetyltransferases. Significant differences in human NAT activity resulting from genetic polymorphisms in both NAT1 and NAT2 can render substrates toxic in certain individuals while non-toxic in others. It is necessary to consider the combination of oxidative and acetyltransferase activities of an individual in determining the safety and efficacy of arylamine drugs in both drug development and in prescribing dosage of existing pharmaceutical agents. Knowledge of the frequency and activity of the major NAT alleles in specific ethnic groups can help guide the selection of a safe and effective dose of drugs that are substrates of these enzymes." @default.
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- W4245199033 date "2001-11-23" @default.
- W4245199033 modified "2023-10-12" @default.
- W4245199033 title "Arylamine Acetyltransferases" @default.
- W4245199033 doi "https://doi.org/10.1002/0470846305.ch11" @default.
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