FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245225559> ?p ?o ?g. }

• W4245225559 endingPage "275" @default.
• W4245225559 startingPage "265" @default.
• W4245225559 abstract "TGF-β1 stimulates thymidine incorporation and the growth rate of mouse NIH3T3 fibroblasts and of those cells transformed by the EJ-H-ras oncogene (TR15 cells), in the presence and the absence of serum. Thymidine incorporation, in serum-deprived cells, is stimulated to a higher degree by 0.1-1 ng/ml of TGF-β in NIH3T3 than in TR15 cells, which have a 10-fold higher basal level of incorporation. In both cell types TGF-β1 is as active, or more active than other mitogens (TGF-α, PDGF-AB, bFGF) at the same concentration. The growth rate of NIH3T3 cells, in low serum or serum-free (S−) medium, is stimulated by only 10 picograms/ml of TGF-β1, and that of TR15 cells, in S− medium, by only 1 picogram/m1. In contrast, TGF-β1 inhibits mitogenically unestablished mouse embryo fibroblasts and these fibroblasts immortalized spontaneously and able to grow in S− medium. It also inhibits the anchorage-independent growth of TR15 cells. NIH3T3 and TR15 cells respond, similarly, to TGF-β activated by acification of their culture medium. The kinetics of thymidine incorporation and of activation of the c-myc proto-oncogene, observed already after 1 hr, in treated NIH3T3 and TR15 cells, suggests a direct mitogenic stimulation. The level of activated c-myc RNA is 2-fold higher at 2 hr, and subsequently decreases relatively less in the TR15 cells." @default.
• W4245225559 created "2022-05-12" @default.
• W4245225559 creator A5006783317 @default.
• W4245225559 creator A5011963860 @default.
• W4245225559 creator A5025040509 @default.
• W4245225559 creator A5053216437 @default.
• W4245225559 creator A5075000531 @default.
• W4245225559 creator A5090000768 @default.
• W4245225559 date "1992-01-01" @default.
• W4245225559 modified "2023-10-18" @default.
• W4245225559 title "Transforming Growth Factor Beta Stimulates Mitogenically Mouse NIH3T3 Fibroblasts and Those Cells Transformed by the EJ-H-ras Oncogene" @default.
• W4245225559 cites W1506960040 @default.
• W4245225559 cites W1935931645 @default.
• W4245225559 cites W1965372133 @default.
• W4245225559 cites W1974321323 @default.
• W4245225559 cites W1989842486 @default.
• W4245225559 cites W1992172901 @default.
• W4245225559 cites W2022886502 @default.
• W4245225559 cites W2042300235 @default.
• W4245225559 cites W2042400223 @default.
• W4245225559 cites W2044946668 @default.
• W4245225559 cites W2057729296 @default.
• W4245225559 cites W2058812508 @default.
• W4245225559 cites W2093519427 @default.
• W4245225559 cites W2095850742 @default.
• W4245225559 cites W2106480106 @default.
• W4245225559 cites W2130227763 @default.
• W4245225559 cites W2136819827 @default.
• W4245225559 cites W2156202773 @default.
• W4245225559 cites W4211166816 @default.
• W4245225559 cites W4232777855 @default.
• W4245225559 doi "https://doi.org/10.3109/08977199209026933" @default.
• W4245225559 hasPublicationYear "1992" @default.
• W4245225559 type Work @default.
• W4245225559 citedByCount "7" @default.
• W4245225559 countsByYear W42452255592012 @default.
• W4245225559 countsByYear W42452255592020 @default.
• W4245225559 crossrefType "journal-article" @default.
• W4245225559 hasAuthorship W4245225559A5006783317 @default.
• W4245225559 hasAuthorship W4245225559A5011963860 @default.
• W4245225559 hasAuthorship W4245225559A5025040509 @default.
• W4245225559 hasAuthorship W4245225559A5053216437 @default.
• W4245225559 hasAuthorship W4245225559A5075000531 @default.
• W4245225559 hasAuthorship W4245225559A5090000768 @default.
• W4245225559 hasConcept C118131993 @default.
• W4245225559 hasConcept C126322002 @default.
• W4245225559 hasConcept C134018914 @default.
• W4245225559 hasConcept C1491633281 @default.
• W4245225559 hasConcept C153911025 @default.
• W4245225559 hasConcept C185592680 @default.
• W4245225559 hasConcept C196843134 @default.
• W4245225559 hasConcept C202751555 @default.
• W4245225559 hasConcept C24998067 @default.
• W4245225559 hasConcept C2776746612 @default.
• W4245225559 hasConcept C2777108182 @default.
• W4245225559 hasConcept C2778024521 @default.
• W4245225559 hasConcept C2779306644 @default.
• W4245225559 hasConcept C2780381497 @default.
• W4245225559 hasConcept C2781018059 @default.
• W4245225559 hasConcept C29537977 @default.
• W4245225559 hasConcept C51296783 @default.
• W4245225559 hasConcept C54009773 @default.
• W4245225559 hasConcept C54355233 @default.
• W4245225559 hasConcept C55493867 @default.
• W4245225559 hasConcept C71924100 @default.
• W4245225559 hasConcept C81885089 @default.
• W4245225559 hasConcept C86803240 @default.
• W4245225559 hasConcept C95444343 @default.
• W4245225559 hasConceptScore W4245225559C118131993 @default.
• W4245225559 hasConceptScore W4245225559C126322002 @default.
• W4245225559 hasConceptScore W4245225559C134018914 @default.
• W4245225559 hasConceptScore W4245225559C1491633281 @default.
• W4245225559 hasConceptScore W4245225559C153911025 @default.
• W4245225559 hasConceptScore W4245225559C185592680 @default.
• W4245225559 hasConceptScore W4245225559C196843134 @default.
• W4245225559 hasConceptScore W4245225559C202751555 @default.
• W4245225559 hasConceptScore W4245225559C24998067 @default.
• W4245225559 hasConceptScore W4245225559C2776746612 @default.
• W4245225559 hasConceptScore W4245225559C2777108182 @default.
• W4245225559 hasConceptScore W4245225559C2778024521 @default.
• W4245225559 hasConceptScore W4245225559C2779306644 @default.
• W4245225559 hasConceptScore W4245225559C2780381497 @default.
• W4245225559 hasConceptScore W4245225559C2781018059 @default.
• W4245225559 hasConceptScore W4245225559C29537977 @default.
• W4245225559 hasConceptScore W4245225559C51296783 @default.
• W4245225559 hasConceptScore W4245225559C54009773 @default.
• W4245225559 hasConceptScore W4245225559C54355233 @default.
• W4245225559 hasConceptScore W4245225559C55493867 @default.
• W4245225559 hasConceptScore W4245225559C71924100 @default.
• W4245225559 hasConceptScore W4245225559C81885089 @default.
• W4245225559 hasConceptScore W4245225559C86803240 @default.
• W4245225559 hasConceptScore W4245225559C95444343 @default.
• W4245225559 hasIssue "3" @default.
• W4245225559 hasLocation W42452255591 @default.
• W4245225559 hasOpenAccess W4245225559 @default.
• W4245225559 hasPrimaryLocation W42452255591 @default.
• W4245225559 hasRelatedWork W1715997950 @default.
• W4245225559 hasRelatedWork W1999149485 @default.

• next