Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245229780> ?p ?o ?g. }
- W4245229780 endingPage "2950" @default.
- W4245229780 startingPage "2943" @default.
- W4245229780 abstract "Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its known antiangiogenic effects, the mechanism of its anti-MM activity is unclear. These studies demonstrate clinical activity of Thal against MM that is refractory to conventional therapy and delineate mechanisms of anti-tumor activity of Thal and its potent analogs (immunomodulatory drugs [IMiDs]). Importantly, these agents act directly, by inducing apoptosis or G1 growth arrest, in MM cell lines and in patient MM cells that are resistant to melphalan, doxorubicin, and dexamethasone (Dex). Moreover, Thal and the IMiDs enhance the anti-MM activity of Dex and, conversely, are inhibited by interleukin 6. As for Dex, apoptotic signaling triggered by Thal and the IMiDs is associated with activation of related adhesion focal tyrosine kinase. These studies establish the framework for the development and testing of Thal and the IMiDs in a new treatment paradigm to target both the tumor cell and the microenvironment, overcome classical drug resistance, and achieve improved outcome in this presently incurable disease." @default.
- W4245229780 created "2022-05-12" @default.
- W4245229780 creator A5006765393 @default.
- W4245229780 creator A5019802024 @default.
- W4245229780 creator A5027328800 @default.
- W4245229780 creator A5032165288 @default.
- W4245229780 creator A5032464400 @default.
- W4245229780 creator A5034560778 @default.
- W4245229780 creator A5043526996 @default.
- W4245229780 creator A5052048627 @default.
- W4245229780 creator A5073391094 @default.
- W4245229780 creator A5078883724 @default.
- W4245229780 creator A5081299017 @default.
- W4245229780 creator A5081617768 @default.
- W4245229780 creator A5091207345 @default.
- W4245229780 date "2000-11-01" @default.
- W4245229780 modified "2023-09-28" @default.
- W4245229780 title "Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy" @default.
- W4245229780 cites W1490737928 @default.
- W4245229780 cites W1520422891 @default.
- W4245229780 cites W1568733499 @default.
- W4245229780 cites W1568956696 @default.
- W4245229780 cites W1966598311 @default.
- W4245229780 cites W1983492903 @default.
- W4245229780 cites W1984996099 @default.
- W4245229780 cites W1985147506 @default.
- W4245229780 cites W2003757684 @default.
- W4245229780 cites W2045560618 @default.
- W4245229780 cites W2047001228 @default.
- W4245229780 cites W2053648381 @default.
- W4245229780 cites W2066529195 @default.
- W4245229780 cites W2076940668 @default.
- W4245229780 cites W2090786978 @default.
- W4245229780 cites W2122596233 @default.
- W4245229780 cites W2125559109 @default.
- W4245229780 cites W2291996831 @default.
- W4245229780 cites W2316160054 @default.
- W4245229780 cites W4230706639 @default.
- W4245229780 cites W4240581684 @default.
- W4245229780 cites W4241333820 @default.
- W4245229780 cites W4244071510 @default.
- W4245229780 cites W4244689496 @default.
- W4245229780 cites W4313376856 @default.
- W4245229780 cites W84008997 @default.
- W4245229780 cites W91158829 @default.
- W4245229780 doi "https://doi.org/10.1182/blood.v96.9.2943.h8002943_2943_2950" @default.
- W4245229780 hasPublicationYear "2000" @default.
- W4245229780 type Work @default.
- W4245229780 citedByCount "22" @default.
- W4245229780 countsByYear W42452297802013 @default.
- W4245229780 countsByYear W42452297802021 @default.
- W4245229780 crossrefType "journal-article" @default.
- W4245229780 hasAuthorship W4245229780A5006765393 @default.
- W4245229780 hasAuthorship W4245229780A5019802024 @default.
- W4245229780 hasAuthorship W4245229780A5027328800 @default.
- W4245229780 hasAuthorship W4245229780A5032165288 @default.
- W4245229780 hasAuthorship W4245229780A5032464400 @default.
- W4245229780 hasAuthorship W4245229780A5034560778 @default.
- W4245229780 hasAuthorship W4245229780A5043526996 @default.
- W4245229780 hasAuthorship W4245229780A5052048627 @default.
- W4245229780 hasAuthorship W4245229780A5073391094 @default.
- W4245229780 hasAuthorship W4245229780A5078883724 @default.
- W4245229780 hasAuthorship W4245229780A5081299017 @default.
- W4245229780 hasAuthorship W4245229780A5081617768 @default.
- W4245229780 hasAuthorship W4245229780A5091207345 @default.
- W4245229780 hasConcept C126322002 @default.
- W4245229780 hasConcept C185592680 @default.
- W4245229780 hasConcept C190283241 @default.
- W4245229780 hasConcept C2776364478 @default.
- W4245229780 hasConcept C2776694085 @default.
- W4245229780 hasConcept C2778684742 @default.
- W4245229780 hasConcept C2779609412 @default.
- W4245229780 hasConcept C2780401358 @default.
- W4245229780 hasConcept C2781303535 @default.
- W4245229780 hasConcept C502942594 @default.
- W4245229780 hasConcept C55493867 @default.
- W4245229780 hasConcept C71924100 @default.
- W4245229780 hasConcept C98274493 @default.
- W4245229780 hasConceptScore W4245229780C126322002 @default.
- W4245229780 hasConceptScore W4245229780C185592680 @default.
- W4245229780 hasConceptScore W4245229780C190283241 @default.
- W4245229780 hasConceptScore W4245229780C2776364478 @default.
- W4245229780 hasConceptScore W4245229780C2776694085 @default.
- W4245229780 hasConceptScore W4245229780C2778684742 @default.
- W4245229780 hasConceptScore W4245229780C2779609412 @default.
- W4245229780 hasConceptScore W4245229780C2780401358 @default.
- W4245229780 hasConceptScore W4245229780C2781303535 @default.
- W4245229780 hasConceptScore W4245229780C502942594 @default.
- W4245229780 hasConceptScore W4245229780C55493867 @default.
- W4245229780 hasConceptScore W4245229780C71924100 @default.
- W4245229780 hasConceptScore W4245229780C98274493 @default.
- W4245229780 hasIssue "9" @default.
- W4245229780 hasLocation W42452297801 @default.
- W4245229780 hasOpenAccess W4245229780 @default.
- W4245229780 hasPrimaryLocation W42452297801 @default.
- W4245229780 hasRelatedWork W1576670771 @default.
- W4245229780 hasRelatedWork W1964222047 @default.
- W4245229780 hasRelatedWork W1976118219 @default.