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- W4245244758 abstract "Despite numerous theories on the pathogenesis of migraine, the exact site of origin of a migraine attack remains unknown. Although most attention has been directed toward the peripheral nervous system, the central nervous system plays an important though incompletely understood role. There are a variety of types of migraine, but similar mechanisms seem to operate in all variants. Based on present evidence, the symp-, toms of migraine are related to a disturbance of the central vasomotor centers, the extracranial and intracranial blood vessels, and the microcirculation.<sup>1,2</sup>Each attack represents an initial phase of arterial vasoconstriction, largely intracranial, and associated with a slowly spreading process of cortical depression accounting for the slow progressive march of neurological symptoms, followed by a phase of painful arterial vasodilatation with increased blood flow of the extracranial or scalp arteries associated with a localized sterile inflammation of the arterial wall. However, this traditional view that" @default.
- W4245244758 created "2022-05-12" @default.
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- W4245244758 date "1972-12-11" @default.
- W4245244758 modified "2023-10-14" @default.
- W4245244758 title "Migraine headaches" @default.
- W4245244758 doi "https://doi.org/10.1001/jama.222.11.1399" @default.
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