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- W4245250347 abstract "Abstract Background: The outbreak of 2019-novel coronavirus has led to a high demand for finding effective antiviral agents. Preliminary experiments showed that Arbidol could inhibit coronavirus replication in vivo. There is limited data on the clinical efficacy of 2019-novel coronavirus-infected pneumonia (NCP). Therefore, we aimed to evaluate this medication based on clinical and laboratory results. Methods: The present study was designed as a clinical trial to investigate the advantages and disadvantages of this medicine compared to empirical treatment. For this purpose, multi-stage sampling was considered. 56 people were selected by accidental non-random sampling method. This sample size was subsequently divided into two groups by randomized block sampling (1:1). During the study, three patients left the case group. Their clinical symptoms were examined while taking these medicines in the disease course. The SPSS software was used for data analysis and the significance level was considered to be P<0.05. Results: On the seventh day, there were statistically significant differences in dry cough(p = 0.001), weakness(p = 0.004), gastrointestinal symptoms(p = 0.043) and shortness of breath (p = 0.001) between the two groups, and the Arbidol group had a faster recovery. During the disease course, there were statistically significant differences in Myalgia(p = 0.03), gastrointestinal symptoms(p = 0.047), and weakness(p = 0.007) were significantly different between the two groups. Conclusion: Symptoms improved faster in patients with mild to moderate disease who received Arbidol in their treatment regimen. In other words, adding Arbidol to the empirical treatment accelerated the recovery process of patients’ clinical symptoms. Registration: IR.TUMS.VCR.REC.1399.204, 04.13.2020 , http://ethics.research.ac.ir/IR.TUMS.VCR.REC.1399.204" @default.
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- W4245250347 date "2020-10-19" @default.
- W4245250347 modified "2023-10-18" @default.
- W4245250347 title "Efficacy and Safety of Arbidol in Treatment of Patients with COVID-19 Infection: A Randomized Clinical Trial" @default.
- W4245250347 doi "https://doi.org/10.21203/rs.3.rs-91430/v1" @default.
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