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- W4245277043 abstract "Important characteristics for ideal skin preparations include long-lasting antimicrobial efficacy and low potential for skin irritation.A total of 55 healthy adult subjects were enrolled to evaluate the antimicrobial effects of 3 test formulations applied to inguinal, abdominal, and antecubital sites at post-treatment time points of 30 seconds, 72 hours, and 7 days. To investigate skin irritation potential, the 3 formulations were tested in a 21-day repeat-insult patch test conducted on the skin of the backs of 23 healthy subjects.The mean log10 reduction (MLR) at 7 days post-treatment produced by a 79% vol/vol ethanol containing 1% wt/vol chlorhexidine gluconate (1% CHG-EtOH) applied to abdominal sites was significantly superior to that produced by a 10% povidone-iodine solution (2.45 MLR vs 0.90 MLR; P < .05). The 1% CHG-EtOH and a 70% vol/vol isopropanol containing 2% wt/vol CHG (2% CHG-IPA) provided statistically equivalent persistence at 72 hours and 7 days post-treatment. The 1% CHG-EtOH had less skin irritation poetntial than the 2% CHG-IPA and the 10% povidone-iodine solution, although the differences were not statistically significant (P > .05).Considering its persistent effect and low skin irritation potential, the 1% CHG-EtOH preparation is expected to perform well in surgical site preparation to reduce the risk of surgery- and catheter-related bloodstream infection." @default.
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- W4245277043 date "2006-09-01" @default.
- W4245277043 modified "2023-09-30" @default.
- W4245277043 title "Skin Preparation" @default.
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- W4245277043 doi "https://doi.org/10.1016/j.cpen.2006.05.003" @default.
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