FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245280695> ?p ?o ?g. }

• W4245280695 endingPage "460" @default.
• W4245280695 startingPage "454" @default.
• W4245280695 abstract "Abstract We investigated the role of adhesion molecules in the early phase of reperfusion following cold ischemia. Livers of male Lewis rats were preserved for 0 h (group A) or 24 h in University of Wisconsin (UW) solution without additives (group B) or in UW solution with anti-ICAM-1 antibody (group C) or anti-E-selectin-1, SLex and SLea antibodies (group D). The livers were then reperfused with diluted rat whole blood (DWB; groups A and B), DWB containing anti-ICAM-1 and LFA-1 antibodies (group C) or DWB containing anti-L-selectin, SLex and SLea antibodies (group D). The reperfusion was performed at 37 °C for 1 h at 5 cm H2O of perfusion pressure. During reperfusion, hepatic microcirculation was assessed by monitoring portal and peripheral tissue blood flow. Bile production was significantly reduced in group B livers compared with those in group A. Anti-ICAM-1 and LFA-1 antibodies failed to improve hepatic microcirculation, whereas anti-LECAM-1, SLex and SLea antibodies significantly improved the microcirculation. Bile production in group C and D livers was comparable to that in group B livers. Preservation for 24 h significantly increased the release of TNF-α from 0.207 to 43.7 pg/g per hour during reperfusion. Monoclonal antibodies to the adhesion molecules did not suppress the release of TNF-α in groups C and D. Histological examination demonstrated a lack of leukocyte infiltration or thrombus in hetapic microvessels. The extent of hepatocyte necrosis did not differ among groups B, C, and D. We conclude that the microcirculatory disturbance in the early phase of reperfusion occurs as a result of the tethering of leukocytes through the interaction of the selectin family and their ligands, and that the ICAM-1-LFA-1 pathway is not involved in this step. The lack of improvement in bile production with antibodies to the selectin family and their ligands strongly suggests that other mechanisms participate in the deterioration of hepatic function." @default.
• W4245280695 created "2022-05-12" @default.
• W4245280695 creator A5012647170 @default.
• W4245280695 creator A5027479479 @default.
• W4245280695 creator A5078005219 @default.
• W4245280695 creator A5082129513 @default.
• W4245280695 date "1996-09-01" @default.
• W4245280695 modified "2023-10-14" @default.
• W4245280695 title "Impact of adhesion molecules of the selectin family on liver microcirculation at reperfusion following cold ischemia" @default.
• W4245280695 cites W1574945736 @default.
• W4245280695 cites W1806496211 @default.
• W4245280695 cites W1966286149 @default.
• W4245280695 cites W1985534693 @default.
• W4245280695 cites W1991365557 @default.
• W4245280695 cites W1994521388 @default.
• W4245280695 cites W1995702637 @default.
• W4245280695 cites W2001720727 @default.
• W4245280695 cites W2007181246 @default.
• W4245280695 cites W2011463782 @default.
• W4245280695 cites W2026853612 @default.
• W4245280695 cites W2029285815 @default.
• W4245280695 cites W2030422115 @default.
• W4245280695 cites W2032371793 @default.
• W4245280695 cites W2032831335 @default.
• W4245280695 cites W2042016806 @default.
• W4245280695 cites W2047916715 @default.
• W4245280695 cites W2060038547 @default.
• W4245280695 cites W2060217665 @default.
• W4245280695 cites W2061140050 @default.
• W4245280695 cites W2070030638 @default.
• W4245280695 cites W2071177681 @default.
• W4245280695 cites W2073743045 @default.
• W4245280695 cites W2080780289 @default.
• W4245280695 cites W2083650107 @default.
• W4245280695 cites W2085233986 @default.
• W4245280695 cites W2100994529 @default.
• W4245280695 cites W2116925086 @default.
• W4245280695 cites W2130077356 @default.
• W4245280695 cites W2139666587 @default.
• W4245280695 cites W2153450942 @default.
• W4245280695 cites W2163361020 @default.
• W4245280695 cites W2168566305 @default.
• W4245280695 cites W4244973993 @default.
• W4245280695 cites W4246991801 @default.
• W4245280695 cites W4247518355 @default.
• W4245280695 doi "https://doi.org/10.1111/j.1432-2277.1996.tb00988.x" @default.
• W4245280695 hasPublicationYear "1996" @default.
• W4245280695 type Work @default.
• W4245280695 citedByCount "0" @default.
• W4245280695 crossrefType "journal-article" @default.
• W4245280695 hasAuthorship W4245280695A5012647170 @default.
• W4245280695 hasAuthorship W4245280695A5027479479 @default.
• W4245280695 hasAuthorship W4245280695A5078005219 @default.
• W4245280695 hasAuthorship W4245280695A5082129513 @default.
• W4245280695 hasConcept C113278225 @default.
• W4245280695 hasConcept C126322002 @default.
• W4245280695 hasConcept C12722491 @default.
• W4245280695 hasConcept C142724271 @default.
• W4245280695 hasConcept C146957229 @default.
• W4245280695 hasConcept C159654299 @default.
• W4245280695 hasConcept C16224149 @default.
• W4245280695 hasConcept C185592680 @default.
• W4245280695 hasConcept C202751555 @default.
• W4245280695 hasConcept C203014093 @default.
• W4245280695 hasConcept C2776200302 @default.
• W4245280695 hasConcept C2780114680 @default.
• W4245280695 hasConcept C3018697912 @default.
• W4245280695 hasConcept C541997718 @default.
• W4245280695 hasConcept C55493867 @default.
• W4245280695 hasConcept C56701166 @default.
• W4245280695 hasConcept C71924100 @default.
• W4245280695 hasConcept C89560881 @default.
• W4245280695 hasConceptScore W4245280695C113278225 @default.
• W4245280695 hasConceptScore W4245280695C126322002 @default.
• W4245280695 hasConceptScore W4245280695C12722491 @default.
• W4245280695 hasConceptScore W4245280695C142724271 @default.
• W4245280695 hasConceptScore W4245280695C146957229 @default.
• W4245280695 hasConceptScore W4245280695C159654299 @default.
• W4245280695 hasConceptScore W4245280695C16224149 @default.
• W4245280695 hasConceptScore W4245280695C185592680 @default.
• W4245280695 hasConceptScore W4245280695C202751555 @default.
• W4245280695 hasConceptScore W4245280695C203014093 @default.
• W4245280695 hasConceptScore W4245280695C2776200302 @default.
• W4245280695 hasConceptScore W4245280695C2780114680 @default.
• W4245280695 hasConceptScore W4245280695C3018697912 @default.
• W4245280695 hasConceptScore W4245280695C541997718 @default.
• W4245280695 hasConceptScore W4245280695C55493867 @default.
• W4245280695 hasConceptScore W4245280695C56701166 @default.
• W4245280695 hasConceptScore W4245280695C71924100 @default.
• W4245280695 hasConceptScore W4245280695C89560881 @default.
• W4245280695 hasIssue "5" @default.
• W4245280695 hasLocation W42452806951 @default.
• W4245280695 hasOpenAccess W4245280695 @default.
• W4245280695 hasPrimaryLocation W42452806951 @default.
• W4245280695 hasRelatedWork W2008363543 @default.
• W4245280695 hasRelatedWork W2026008412 @default.
• W4245280695 hasRelatedWork W2051818058 @default.
• W4245280695 hasRelatedWork W2077591403 @default.

• next