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• W4245308691 abstract "We here applied FDG-PET as well as BF-227 PET, an amyloid tracer, to the same subjects (aged normal (AN), mild cognitive impairment (MCI), and Alzheimer's disease (AD)) and carefully analyzed and compared the results with these two kinds of PET. Using these data we investigated and compared the specificity and sensitivity of BF-227 PET and FDG-PET in diagnosing AD. The diagnosis for MCI and probable AD followed the MCI clinical criteria presented by Petersen et al. (Petersen et al. 1999) and National Institute of Neurological and Communication Disorders, Alzheimer's Disease and Related Disorders Association (McKhann et al. 1984), respectively. [11C]-BF-227 was synthesized from the precursor by N-methylation in dimethyl sulfoxide using [11C]-methyl triflate. The [11C]-BF-227 PET study was performed using a PET SET-2400W scanner (Shimadzu Inc., Japan).Cerebral glucose metabolism was measured using 18F-FDG and a PET scanner SET-2400W. Subjects were scanned in a quiet and dimly-lit room with their eyes closed after at least four hours of food restriction. Patients with MCI subjects showed significantly increased accumulation of [11C]-BF-227 compared to AN in frontal, temporal, parietal, and occipital cortices as well as anterior and posterior cingulate gyrus. On the other hand SUV-R of BF-227 was lower in MCI compared to AD in lateral temporal, parietal, and occipital cortices, posterior cingulate gyrus, and striatum. SUV-R of BF-227 was negatively correlated with that of FDG when we analyzed the data from all the subjects (AN, MCI, and AD) together. The specificity and sensitivity for diagnosis of AD with BF-227 were significantly better than those with FDG-PET. We conclude that BF-227 PET is a useful technology in diagnosing MCI or an early stage of AD with very little invasion. These results indicate that MCI has intermediate retention of 11C-BF-227 between AN and AD indicating that Aβ deposition already started in the stage of MCI before dementia symptoms become obvious." @default.
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• W4245308691 date "2009-07-01" @default.
• W4245308691 modified "2023-09-23" @default.
• W4245308691 title "P3-082: PET imaging for mild cognitive impairment with FDG and beta-amyloid tracer, 11C-BF-227" @default.
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• W4245308691 doi "https://doi.org/10.1016/j.jalz.2009.04.1158" @default.
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