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- W4245367061 abstract "Abstract BackgroundThe EMPOWER trial aimed to assess the effects of a 9-week exercise prehabilitation programme on physical fitness compared with a usual care control group. Secondary aims were to investigate the effect of 1) the exercise prehabilitation programme on psychological health; and 2) neoadjuvant chemoradiotherapy (NCRT) on physical fitness and psychological health.MethodsBetween October 2013 and December 2016, adults with locally advanced rectal cancer undergoing standardised NCRT and surgery were recruited to a multi-centre trial. Patients underwent cardiopulmonary exercise testing (CPET) and HRQoL questionnaires (EORTC-QLQ-C30 and EQ-5D-5L) pre-NCRT and post-NCRT (week 0/baseline). At week 0, patients were randomised to exercise prehabilitation or usual care (no intervention). CPET and HRQoL questionnaires were assessed at week 0, 3, 6 and 9, whilst semi structured interviews were assessed at week 0 and week 9. Changes in oxygen uptake at anaerobic threshold (VO 2 at AT (ml.kg − 1 .min − 1 )) between groups was compared using linear mixed modelling.ResultsThirty-eight patients were recruited, mean age 64 (10.4) years. Of the 38 patients, 33 were randomised: 16 to usual care and 17 to exercise prehabilitation (26 male and seven female). Exercise prehabilitation significantly improved VO 2 at AT compared to the usual care. The change from baseline to week 9, when adjusted for baseline, between the randomised groups was + 2.9 ml.kg − 1 .min − 1 ; 95% CI (0.8 to 5.1); p = 0.011.ConclusionA 9-week exercise prehabilitation programme significantly rescued fitness following NCRT. These findings have informed the WesFit trial (NCT03509428) which is investigating the effects of community-based multimodal prehabilitation before cancer surgery.Trial registrationClinicalTrials.gov NCT01914068. Registered 1 August 2013, https://clinicaltrials.gov/ct2/show/NCT01914068." @default.
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- W4245367061 date "2020-08-26" @default.
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- W4245367061 title "The effects of neoadjuvant chemoradiotherapy and an in-hospital exercise training programme on physical fitness and quality of life in locally advanced rectal cancer patients: A randomised controlled trial (The EMPOWER Trial)" @default.
- W4245367061 doi "https://doi.org/10.21203/rs.3.rs-59458/v1" @default.
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