Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245433337> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4245433337 abstract "Abstract Background Pulmonary hypertension worsens the prognosis of idiopathic pulmonary fibrosis (IPF) and is associated with chronic respiratory failure in advanced disease. However, little is known about the occurrence of pulmonary hypertension and subsequent right ventricular dysfunction in non-advanced IPF patients without hypoxemia at rest. We evaluated right ventricular dysfunction in non-advanced IPF patients and examined the association of right ventricular dysfunction with mean pulmonary artery pressure (mPAP) at rest and during exercise.Methods This cross-sectional study included patients with blood oxygen saturation levels ≥92% at rest, Gender-Age-Physiology Index score ≤5, modified Medical Research Council dyspnea scale score ≤3, and no history of oxygen therapy. Patients underwent transthoracic echocardiography at rest and during cardiopulmonary exercise. Ventricular function was analyzed by measuring conventional parameters and right ventricular global longitudinal strain using two-dimensional speckle-tracking echocardiography. Means were compared using t-test for independent samples. Results Abnormal speckle-tracking echocardiography findings were identified in 10/27 patients (37%), indicating right ventricular dysfunction (mean mPAP: 21.6 ± 5.5 mmHg at rest, 42.2 ± 14.1 mmHg during maximal exercise). Significant differences in mPAP were observed between patients with right ventricular dysfunction and those without dysfunction (at rest: 26.0 ± 4.8 vs. 19.1 ± 4.2 mmHg, p = 0.001; during exercise: 51.3 ± 6.4 vs. 36.9 ± 14.7 mmHg, p = 0.002). Right ventricular dysfunction was detected in 37% of non-advanced IPF patients and was associated with increased mPAP at rest and during exercise. Early recognition was only possible using speckle-tracking echocardiography. Conclusions Right ventricular dysfunction was detected in 37% of non-advanced IPF patients and was associated with increased mPAP at rest and during exercise. Special attention should be given to these patients; as right ventricular dysfunction is suggestive of worse prognosis. These patients could benefit from new specific drugs or even oxygen therapy for transitory hypoxia." @default.
- W4245433337 created "2022-05-12" @default.
- W4245433337 creator A5003077674 @default.
- W4245433337 creator A5007711641 @default.
- W4245433337 creator A5010723310 @default.
- W4245433337 creator A5038447711 @default.
- W4245433337 creator A5060232490 @default.
- W4245433337 creator A5069918723 @default.
- W4245433337 creator A5081847941 @default.
- W4245433337 date "2020-04-15" @default.
- W4245433337 modified "2023-09-27" @default.
- W4245433337 title "Right ventricular dysfunction in patients with non-severe idiopathic pulmonary fibrosis: a cross-sectional prospective single-center study" @default.
- W4245433337 doi "https://doi.org/10.21203/rs.2.15809/v2" @default.
- W4245433337 hasPublicationYear "2020" @default.
- W4245433337 type Work @default.
- W4245433337 citedByCount "0" @default.
- W4245433337 crossrefType "posted-content" @default.
- W4245433337 hasAuthorship W4245433337A5003077674 @default.
- W4245433337 hasAuthorship W4245433337A5007711641 @default.
- W4245433337 hasAuthorship W4245433337A5010723310 @default.
- W4245433337 hasAuthorship W4245433337A5038447711 @default.
- W4245433337 hasAuthorship W4245433337A5060232490 @default.
- W4245433337 hasAuthorship W4245433337A5069918723 @default.
- W4245433337 hasAuthorship W4245433337A5081847941 @default.
- W4245433337 hasBestOaLocation W42454333371 @default.
- W4245433337 hasConcept C126322002 @default.
- W4245433337 hasConcept C164705383 @default.
- W4245433337 hasConcept C2776779939 @default.
- W4245433337 hasConcept C2777714996 @default.
- W4245433337 hasConcept C2778198053 @default.
- W4245433337 hasConcept C2778296771 @default.
- W4245433337 hasConcept C2778341716 @default.
- W4245433337 hasConcept C2780930700 @default.
- W4245433337 hasConcept C2780940725 @default.
- W4245433337 hasConcept C71924100 @default.
- W4245433337 hasConcept C78085059 @default.
- W4245433337 hasConceptScore W4245433337C126322002 @default.
- W4245433337 hasConceptScore W4245433337C164705383 @default.
- W4245433337 hasConceptScore W4245433337C2776779939 @default.
- W4245433337 hasConceptScore W4245433337C2777714996 @default.
- W4245433337 hasConceptScore W4245433337C2778198053 @default.
- W4245433337 hasConceptScore W4245433337C2778296771 @default.
- W4245433337 hasConceptScore W4245433337C2778341716 @default.
- W4245433337 hasConceptScore W4245433337C2780930700 @default.
- W4245433337 hasConceptScore W4245433337C2780940725 @default.
- W4245433337 hasConceptScore W4245433337C71924100 @default.
- W4245433337 hasConceptScore W4245433337C78085059 @default.
- W4245433337 hasLocation W42454333371 @default.
- W4245433337 hasLocation W42454333372 @default.
- W4245433337 hasLocation W42454333373 @default.
- W4245433337 hasOpenAccess W4245433337 @default.
- W4245433337 hasPrimaryLocation W42454333371 @default.
- W4245433337 hasRelatedWork W1254051369 @default.
- W4245433337 hasRelatedWork W2106346448 @default.
- W4245433337 hasRelatedWork W2113753962 @default.
- W4245433337 hasRelatedWork W2123957579 @default.
- W4245433337 hasRelatedWork W2595015254 @default.
- W4245433337 hasRelatedWork W2884132629 @default.
- W4245433337 hasRelatedWork W2911151436 @default.
- W4245433337 hasRelatedWork W3007425150 @default.
- W4245433337 hasRelatedWork W4252541677 @default.
- W4245433337 hasRelatedWork W68357867 @default.
- W4245433337 isParatext "false" @default.
- W4245433337 isRetracted "false" @default.
- W4245433337 workType "article" @default.