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- W4245495456 abstract "Abstract Objective : The aim of our study is to examine the effects of neonatal tactile stimulatons on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy. Methods : In the present research, morphology and density of dendritic spines were analyzed in the somatosensory cortex (SoCx) of WAG/Rij rats (non stimulated control, tactile-stimulated and maternal separated rats) and healthy Wistar (non-epileptic) rats. To achieve this, a Golgi-Cox method was used. Results : Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at post natal day 150 in comparison to non-epileptic adult control Wistar rats (p<0,001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p<0,001). Conclusions : Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat’s brain and suggest a reduction in dendrite spine density is linked to absence seizure reduction." @default.
- W4245495456 created "2022-05-12" @default.
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- W4245495456 date "2021-05-27" @default.
- W4245495456 modified "2023-10-17" @default.
- W4245495456 title "Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats" @default.
- W4245495456 doi "https://doi.org/10.21203/rs.3.rs-47951/v3" @default.
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