Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245526231> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4245526231 endingPage "290" @default.
- W4245526231 startingPage "283" @default.
- W4245526231 abstract "A mechanism is proposed by which apotransferrin is secreted from mucosal cells, loaded with iron in the intestinal lumen, and then the intact complex is taken into the cell. Within the cell, iron is released and transferred to the blood stream, whereas iron-free transferrin returns to the brush border to be recycled. We have investigated this hypothesis by measuring intestinal absorption of radioiron and 125I-labeled plasma transferrin using tied-off gut segments in normal and iron-deficient rats. There was no absorption of diferric transferrin from the ileum, but high absorption from the duodenum and jejunum segments. Jejunal absorption occurred as a function of the dose offered and showed saturation kinetics. In normal animals, 4 micrograms of the 50 micrograms of transferrin iron was absorbed over 1 hr. In iron-deficient animals, mean values as high as 13 micrograms were observed. Radioiron content of the jejunal mucosa bore a linear relationship to the dose administered and was inversely proportional to the amount of iron entering the plasma. Recycling of transferrin was indicated by the presence of labeled apotransferrin in the lumen, first observed between 15 and 60 min after the injection of diferric transferrin. A high resistance of diferric and apotransferrin to proteolytic degradation within the gut lumen was demonstrated. Comparative studies with lactoferrin and ferritin disclosed poor availability of their iron for absorption. The small amount that was absorbed did not relate to the iron status of the recipient animal. These studies support the role of mucosal transferrin as a shuttle protein for iron absorption." @default.
- W4245526231 created "2022-05-12" @default.
- W4245526231 creator A5007184946 @default.
- W4245526231 creator A5023250064 @default.
- W4245526231 creator A5035704926 @default.
- W4245526231 creator A5082470011 @default.
- W4245526231 creator A5082757525 @default.
- W4245526231 date "1983-02-01" @default.
- W4245526231 modified "2023-09-30" @default.
- W4245526231 title "The significance of transferrin for intestinal iron absorption" @default.
- W4245526231 doi "https://doi.org/10.1182/blood.v61.2.283.bloodjournal612283" @default.
- W4245526231 hasPublicationYear "1983" @default.
- W4245526231 type Work @default.
- W4245526231 citedByCount "1" @default.
- W4245526231 countsByYear W42455262312015 @default.
- W4245526231 crossrefType "journal-article" @default.
- W4245526231 hasAuthorship W4245526231A5007184946 @default.
- W4245526231 hasAuthorship W4245526231A5023250064 @default.
- W4245526231 hasAuthorship W4245526231A5035704926 @default.
- W4245526231 hasAuthorship W4245526231A5082470011 @default.
- W4245526231 hasAuthorship W4245526231A5082757525 @default.
- W4245526231 hasBestOaLocation W42455262311 @default.
- W4245526231 hasConcept C121332964 @default.
- W4245526231 hasConcept C125287762 @default.
- W4245526231 hasConcept C126322002 @default.
- W4245526231 hasConcept C131631996 @default.
- W4245526231 hasConcept C134018914 @default.
- W4245526231 hasConcept C153852466 @default.
- W4245526231 hasConcept C185592680 @default.
- W4245526231 hasConcept C22814914 @default.
- W4245526231 hasConcept C24890656 @default.
- W4245526231 hasConcept C2776366702 @default.
- W4245526231 hasConcept C2776809568 @default.
- W4245526231 hasConcept C2777226302 @default.
- W4245526231 hasConcept C2778319317 @default.
- W4245526231 hasConcept C2779170986 @default.
- W4245526231 hasConcept C2779369046 @default.
- W4245526231 hasConcept C3019184707 @default.
- W4245526231 hasConcept C55493867 @default.
- W4245526231 hasConcept C71924100 @default.
- W4245526231 hasConcept C86803240 @default.
- W4245526231 hasConceptScore W4245526231C121332964 @default.
- W4245526231 hasConceptScore W4245526231C125287762 @default.
- W4245526231 hasConceptScore W4245526231C126322002 @default.
- W4245526231 hasConceptScore W4245526231C131631996 @default.
- W4245526231 hasConceptScore W4245526231C134018914 @default.
- W4245526231 hasConceptScore W4245526231C153852466 @default.
- W4245526231 hasConceptScore W4245526231C185592680 @default.
- W4245526231 hasConceptScore W4245526231C22814914 @default.
- W4245526231 hasConceptScore W4245526231C24890656 @default.
- W4245526231 hasConceptScore W4245526231C2776366702 @default.
- W4245526231 hasConceptScore W4245526231C2776809568 @default.
- W4245526231 hasConceptScore W4245526231C2777226302 @default.
- W4245526231 hasConceptScore W4245526231C2778319317 @default.
- W4245526231 hasConceptScore W4245526231C2779170986 @default.
- W4245526231 hasConceptScore W4245526231C2779369046 @default.
- W4245526231 hasConceptScore W4245526231C3019184707 @default.
- W4245526231 hasConceptScore W4245526231C55493867 @default.
- W4245526231 hasConceptScore W4245526231C71924100 @default.
- W4245526231 hasConceptScore W4245526231C86803240 @default.
- W4245526231 hasIssue "2" @default.
- W4245526231 hasLocation W42455262311 @default.
- W4245526231 hasOpenAccess W4245526231 @default.
- W4245526231 hasPrimaryLocation W42455262311 @default.
- W4245526231 hasRelatedWork W1047228 @default.
- W4245526231 hasRelatedWork W1084641 @default.
- W4245526231 hasRelatedWork W1386711 @default.
- W4245526231 hasRelatedWork W20003993 @default.
- W4245526231 hasRelatedWork W2102624 @default.
- W4245526231 hasRelatedWork W24425257 @default.
- W4245526231 hasRelatedWork W4202606 @default.
- W4245526231 hasRelatedWork W4791542 @default.
- W4245526231 hasRelatedWork W8244368 @default.
- W4245526231 hasRelatedWork W8857743 @default.
- W4245526231 hasVolume "61" @default.
- W4245526231 isParatext "false" @default.
- W4245526231 isRetracted "false" @default.
- W4245526231 workType "article" @default.