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• W4245536703 abstract "Preiser disease (PD) is a disease of unknown etiology characterized by avascular necrosis (AVN), also known as osteonecrosis, of the scaphoid bone, described by Preiser 1 Preiser G. Eine typische posttraumatische und zur spontanfraktur fuhrende ostitis des naviculare carpi. Fortschr Geb Roentgenstr. 1910; 15: 189-197 Google Scholar in 1910. Patients typically present with radial-sided wrist pain, scaphoid area tenderness, and reduced wrist motion. 2 Herbert T.J. Lanzetta M. Idiopathic avascular necrosis of the scaphoid. J Hand Surg Br. 1994; 19: 174-182 Crossref PubMed Scopus (64) Google Scholar , 3 Ferlic D.C. Morin P. Idiopathic avascular necrosis of the scaphoid: Preiser's disease?. J Hand Surg Am. 1989; 14: 13-16 Abstract Full Text PDF PubMed Scopus (63) Google Scholar , 4 De Smet L. Aerts P. Walraevens M. Fabry G. Avascular necrosis of the carpal scaphoid: Preiser's disease: report of 6 cases and review of the literature. Acta Orthop Belg. 1993; 59: 139-142 PubMed Google Scholar , 5 Vidal M.A. Linscheid R.L. Amadio P.C. Dobyns J.H. Preiser's disease. Ann Chir Main Memb Super. 1991; 10: 227-235 Crossref PubMed Scopus (45) Google Scholar Plain radiographs may demonstrate scaphoid sclerosis without visible fracture, and magnetic resonance imaging (MRI) shows signal changes in the scaphoid either diffusely or in the proximal pole only. 2 Herbert T.J. Lanzetta M. Idiopathic avascular necrosis of the scaphoid. J Hand Surg Br. 1994; 19: 174-182 Crossref PubMed Scopus (64) Google Scholar , 4 De Smet L. Aerts P. Walraevens M. Fabry G. Avascular necrosis of the carpal scaphoid: Preiser's disease: report of 6 cases and review of the literature. Acta Orthop Belg. 1993; 59: 139-142 PubMed Google Scholar , 6 Kalainov D.M. Cohen M.S. Hendrix R.W. Sweet S. Culp R.W. Osterman A.L. Preiser's disease: identification of two patterns. J Hand Surg Am. 2003; 28: 767-778 Abstract Full Text Full Text PDF PubMed Scopus (49) Google Scholar Late radiographic changes include cystic changes and fragmentation/fracture. There are no single case series large enough to show a definitive gender or hand dominance, although a recent aggregation of existing case series appears to demonstrate a higher incidence in the dominant wrist and in females, and an average age of 42 years (range, 9–76 y). 7 Lenoir H. Coulet B. Lazerges C. Mares O. Croutzet P. Chammas M. Idiopathic avascular necrosis of the scaphoid: 10 new cases and a review of the literature. Indications for Preiser's disease. Orthop Traumatol Surg Res. 2012; 98: 390-397 Crossref PubMed Scopus (22) Google Scholar There are rare reports of PD occurring bilaterally or in conjunction with avascular necrosis of the carpal lunate. 3 Ferlic D.C. Morin P. Idiopathic avascular necrosis of the scaphoid: Preiser's disease?. J Hand Surg Am. 1989; 14: 13-16 Abstract Full Text PDF PubMed Scopus (63) Google Scholar , 8 Budoff J.E. Concomitant Kienbock's and Preiser's diseases: a case report. J Hand Surg Am. 2006; 31: 1149-1153 Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar , 9 Imam S. Aldridge C. Lyall H. Bilateral idiopathic avascular necrosis of the scaphoid: a rare case of Preiser's disease. J Bone Joint Surg Br. 2009; 91: 1400-1402 PubMed Google Scholar The etiology of PD is hypothesized to involve repetitive trauma, steroid use, chemotherapy, trauma, connective tissue disorders, and alcohol intake, all of which are thought to potentially disrupt the blood supply to the scaphoid. 5 Vidal M.A. Linscheid R.L. Amadio P.C. Dobyns J.H. Preiser's disease. Ann Chir Main Memb Super. 1991; 10: 227-235 Crossref PubMed Scopus (45) Google Scholar , 6 Kalainov D.M. Cohen M.S. Hendrix R.W. Sweet S. Culp R.W. Osterman A.L. Preiser's disease: identification of two patterns. J Hand Surg Am. 2003; 28: 767-778 Abstract Full Text Full Text PDF PubMed Scopus (49) Google Scholar , 7 Lenoir H. Coulet B. Lazerges C. Mares O. Croutzet P. Chammas M. Idiopathic avascular necrosis of the scaphoid: 10 new cases and a review of the literature. Indications for Preiser's disease. Orthop Traumatol Surg Res. 2012; 98: 390-397 Crossref PubMed Scopus (22) Google Scholar , 10 Urman J.D. Abeles M. Houghton A.N. Rothfield N.F. Aseptic necrosis presenting as wrist pain in SLE. Arthritis Rheum. 1977; 20: 825-828 Crossref PubMed Scopus (37) Google Scholar Ulnar variance does not appear be a risk factor. 6 Kalainov D.M. Cohen M.S. Hendrix R.W. Sweet S. Culp R.W. Osterman A.L. Preiser's disease: identification of two patterns. J Hand Surg Am. 2003; 28: 767-778 Abstract Full Text Full Text PDF PubMed Scopus (49) Google Scholar , 7 Lenoir H. Coulet B. Lazerges C. Mares O. Croutzet P. Chammas M. Idiopathic avascular necrosis of the scaphoid: 10 new cases and a review of the literature. Indications for Preiser's disease. Orthop Traumatol Surg Res. 2012; 98: 390-397 Crossref PubMed Scopus (22) Google Scholar Schmitt et al, 11 Schmitt R. Frohner S. van Schoonhoven J. Lanz U. Golles A. Idiopathic osteonecrosis of the scaphoid (Preiser's disease)—MRI gives new insights into etiology and pathology. Eur J Radiol. 2011; 77: 228-234 Abstract Full Text Full Text PDF PubMed Scopus (18) Google Scholar using contrast MRI, found a “3-layered zone” appearance to PD: The proximal pole was first involved, followed by the waist, and finally, the distal pole." @default.
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