Matches in SemOpenAlex for { <https://semopenalex.org/work/W4245547162> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4245547162 endingPage "II" @default.
- W4245547162 startingPage "I" @default.
- W4245547162 abstract "It is generally agreed that lipid peroxides play an important role in the pathogenesis of ethanol-induced cellular injury and that free sulfhydryl groups are vital in cellular defense against endogenous or exogenous oxidants. It has been observed that oxidative stress induces the synthesis of the 70-kDa family of heat-shock proteins (HSPs). Induction of HSPs represents an essential and highly conserved cellular response to a variety of stressful stimuli. In the present study we measured in various brain areas and in liver the intracellular levels of HSP70 proteins, sulfhydryl groups and the antioxidant enzyme status after chronic administration of mild intoxicating doses of ethanol to rats. Expression of HSP70 in response to alcohol administration was particularly high in the hippocampus and striatum. In these brain areas, the increase in HSP70 protein levels occurred in absence of significant changes of antioxidant enzyme activities and was correlated with a marked depletion of intracellular bound thiols and with a decreased susceptibility to lipid peroxidation. Lower levels of HSP70 induction were found in cortex and cerebellum and were associated to decreases in SOD and CAT enzyme activities, with a lower depletion of protein bound thiols and with an increased susceptibility to lipid peroxidation. This study agrees with our previous results performed on acute alcohol intoxication and supports the hypothesis that HSP70 induction protects the different brain areas against oxidative stress." @default.
- W4245547162 created "2022-05-12" @default.
- W4245547162 date "2003-03-15" @default.
- W4245547162 modified "2023-09-25" @default.
- W4245547162 title "Society for Free Radical Biology and Medicine Info" @default.
- W4245547162 doi "https://doi.org/10.1016/s0891-5849(03)00067-4" @default.
- W4245547162 hasPublicationYear "2003" @default.
- W4245547162 type Work @default.
- W4245547162 citedByCount "0" @default.
- W4245547162 crossrefType "journal-article" @default.
- W4245547162 hasConcept C104317684 @default.
- W4245547162 hasConcept C16613235 @default.
- W4245547162 hasConcept C181199279 @default.
- W4245547162 hasConcept C185592680 @default.
- W4245547162 hasConcept C203014093 @default.
- W4245547162 hasConcept C205260736 @default.
- W4245547162 hasConcept C2776151105 @default.
- W4245547162 hasConcept C2778004101 @default.
- W4245547162 hasConcept C2780829032 @default.
- W4245547162 hasConcept C2780942790 @default.
- W4245547162 hasConcept C55493867 @default.
- W4245547162 hasConcept C68991219 @default.
- W4245547162 hasConcept C79879829 @default.
- W4245547162 hasConcept C86803240 @default.
- W4245547162 hasConcept C98274493 @default.
- W4245547162 hasConceptScore W4245547162C104317684 @default.
- W4245547162 hasConceptScore W4245547162C16613235 @default.
- W4245547162 hasConceptScore W4245547162C181199279 @default.
- W4245547162 hasConceptScore W4245547162C185592680 @default.
- W4245547162 hasConceptScore W4245547162C203014093 @default.
- W4245547162 hasConceptScore W4245547162C205260736 @default.
- W4245547162 hasConceptScore W4245547162C2776151105 @default.
- W4245547162 hasConceptScore W4245547162C2778004101 @default.
- W4245547162 hasConceptScore W4245547162C2780829032 @default.
- W4245547162 hasConceptScore W4245547162C2780942790 @default.
- W4245547162 hasConceptScore W4245547162C55493867 @default.
- W4245547162 hasConceptScore W4245547162C68991219 @default.
- W4245547162 hasConceptScore W4245547162C79879829 @default.
- W4245547162 hasConceptScore W4245547162C86803240 @default.
- W4245547162 hasConceptScore W4245547162C98274493 @default.
- W4245547162 hasIssue "6" @default.
- W4245547162 hasLocation W42455471621 @default.
- W4245547162 hasOpenAccess W4245547162 @default.
- W4245547162 hasPrimaryLocation W42455471621 @default.
- W4245547162 hasRelatedWork W1470000624 @default.
- W4245547162 hasRelatedWork W2049680397 @default.
- W4245547162 hasRelatedWork W2055146579 @default.
- W4245547162 hasRelatedWork W2069460849 @default.
- W4245547162 hasRelatedWork W2113533986 @default.
- W4245547162 hasRelatedWork W2365628549 @default.
- W4245547162 hasRelatedWork W2418192174 @default.
- W4245547162 hasRelatedWork W2506750322 @default.
- W4245547162 hasRelatedWork W2884957776 @default.
- W4245547162 hasRelatedWork W3008968475 @default.
- W4245547162 hasVolume "34" @default.
- W4245547162 isParatext "false" @default.
- W4245547162 isRetracted "false" @default.
- W4245547162 workType "article" @default.