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- W4245607760 abstract "Background: Severe acute pancreatitis (SAP) remains one of the more feared and respected acute surgical conditions, given that patients often have signifcant organ failure and require careful management. Published mortality rates of SAP hover about 20% but some of these studies are more than 10 years old. We seek to review our centre's mortality rate in SAP. Methods: We retrospectively reviewed 411 cases of acute pancreatitis from 2008 to 2016 at a single centre, looking at pancreatitis severity and cause of mortality. Results: Of 411 cases, 41 cases were severe. The series had 7 deaths, all of whom had SAP, making the overall mortality rate 1.7% for pancreatitis and 17% for SAP. Four of the 7 died from overwhelming systemic inflammatory response syndrome (SIRS) and multiorgan failure within the first 10 days and 1 from infected pancreatic necrosis on day 29. One passed away from aspiration as a result of intestinal obstruction from a concurrent sigmoid tumour; another was managed successfully and survived (SIRS) and intensive care, but passed away suddenly on day 24 of admission in the rehabiliatation ward from cardiorespiratory cause. As such the actual mortality directly due to SAP is 12%. Conclusion: Mortality rate for SAP in our centre is lower than published data and this likely reflects better clinical management with improved understanding of the pathophysiology of pancreatitis over the years. We believe many other centres will also show improved mortality rates compared to previously established data." @default.
- W4245607760 created "2022-05-12" @default.
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- W4245607760 date "2019-01-01" @default.
- W4245607760 modified "2023-09-26" @default.
- W4245607760 title "Mortality in Severe Acute Pancreatitis: are we getting better?" @default.
- W4245607760 doi "https://doi.org/10.1016/j.hpb.2019.10.612" @default.
- W4245607760 hasPublicationYear "2019" @default.
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