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- W4245628666 abstract "Abstract Purpose : Accurate dosimetry is essential in radioembolization. To this purpose, an automatic protocol for healthy liver dosimetry based on dual isotope (DI) SPECT imaging, combining holmium-166 ( 166 Ho)-microspheres and technetium-99m ( 99m Tc)-colloid, was developed: 166 Ho-microspheres used as scout and therapeutic particles and 99m Tc-colloid to identify the healthy liver. DI SPECT allows for an automatic and accurate estimation of absorbed doses, introducing true personalized dosimetry. However, photon crosstalk between isotopes can compromise image quality. This study investigates the effect of 99m Tc downscatter on 166 Ho dosimetry, by comparing 166 Ho-SPECT reconstructions of patient scans acquired before ( 166 Ho-only) and after additional administration of 99m Tc-colloid ( 166 Ho-DI). Methods : The 166 Ho-only and 166 Ho-DI scans were performed in short succession by injecting 99m Tc-colloid on the scanner table. To compensate for 99m Tc downscatter, its influence was accounted for in the DI image reconstruction using energy window-based scatter correction methods. The qualitative assessment was performed by independent blinded comparison by two nuclear medicine physicians assessing 65 pairs of SPECT/CT. Inter-observer agreement was tested by Cohen's kappa coefficient. For the quantitative analysis, two volumes of interest within the liver, VOI TUMOR and VOI HEALTHY , were manually delineated on the 166 Ho-only reconstruction and transferred to the co-registered 166 Ho-DI reconstruction. Absorbed dose within the resulting VOIs, and in the lungs (VOI LUNGS ), was calculated based on the administered therapeutic activity. Results : The qualitative assessment showed no distinct clinical preference for either 166 Ho-only or 166 Ho-DI SPECT (kappa=0.093). Quantitative analysis indicated that the mean absorbed dose difference between 166 Ho-DI and 166 Ho-only was -2.00±2.84 Gy (median 27 Gy; p-value <0.00001), -5.27±8.99 Gy (median 116 Gy; p-value =0.00035) and 0.80±1.08 Gy (median 3 Gy; p-value <0.00001) for VOI HEALTHY, VOI TUMOR and VOI LUNGS respectively. The corresponding Pearson’s correlation coefficient between 166 Ho-only and 166 Ho-DI for absorbed dose was 0.97, 0.99 and 0.82, respectively." @default.
- W4245628666 created "2022-05-12" @default.
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- W4245628666 date "2020-06-15" @default.
- W4245628666 modified "2023-09-28" @default.
- W4245628666 title "Quantitative 166Ho-microspheres SPECT derived from a dual-isotope acquisition with 99mTc-colloid is clinically feasible" @default.
- W4245628666 doi "https://doi.org/10.21203/rs.3.rs-20717/v2" @default.
- W4245628666 hasPublicationYear "2020" @default.
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