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- W4245641106 abstract "To test the hypothesis that variants in genes implicated in cognitive function may promote exceptional longevity, we performed a 3-stage study to identify functional longevity-associated variants in ~700 candidate genes in up to 450 centenarians and 500 controls by target capture sequencing analysis. We found an enrichment of longevity-associated genes in the nPKC and NF-kB signaling pathways by gene-based association analyses. Functional analysis of the top three gene variants (NFKBIA, CLU, PRKCH) suggests that non-coding variants reduce signaling through the nPKC and NF-kB." @default.
- W4245641106 created "2022-05-12" @default.
- W4245641106 date "2021-07-01" @default.
- W4245641106 modified "2023-10-17" @default.
- W4245641106 doi "https://doi.org/10.1111/acel.v20.7" @default.
- W4245641106 hasPublicationYear "2021" @default.
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