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- W4245645241 abstract "Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding nicotinamide N-methyltransferase, NNMT, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. NNMT expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. NNMT expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of NNMT is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. NNMT may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression." @default.
- W4245645241 created "2022-05-12" @default.
- W4245645241 creator A5024900493 @default.
- W4245645241 date "2021-07-19" @default.
- W4245645241 modified "2023-09-26" @default.
- W4245645241 title "Differential expression of nicotinamide N-methyltransferase in human epithelial ovarian cancer." @default.
- W4245645241 doi "https://doi.org/10.31219/osf.io/9wf8v" @default.
- W4245645241 hasPublicationYear "2021" @default.
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